ENSMUSG00000049871


Mus musculus

Features
Gene ID: ENSMUSG00000049871
  
Biological name :Nlrc3
  
Synonyms : Nlrc3 / Protein NLRC3 / Q5DU56
  
Possible biological names infered from orthology : NLR family CARD domain containing 3 / Q7RTR2
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 3945007
Gene end: 3976632
  
Corresponding Affymetrix probe sets: 10437272 (MoGene1.0st)   1446689_at (Mouse Genome 430 2.0 Array)   1458148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137325
Ensembl peptide - ENSMUSP00000137628
Ensembl peptide - ENSMUSP00000155241
NCBI entrez gene - 268857     See in Manteia.
MGI - MGI:2444070
RefSeq - XM_011245906
RefSeq - NM_001081280
RefSeq - NM_175547
RefSeq - XM_011245902
RefSeq - XM_011245903
RefSeq Peptide - NP_001074749
RefSeq Peptide - NP_780756
swissprot - Q5DU56
swissprot - J3QQ49
Ensembl - ENSMUSG00000049871
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlrc3ENSDARG00000103146Danio rerio
 NLRC3ENSGALG00000033278Gallus gallus
 NLRC3ENSG00000167984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*ENSMUSG0000005599421
Nlrc5 / C3VPR6 / Protein NLRC5 / Q86WI3* / NLR family CARD domain containing 5*ENSMUSG0000007415119
Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*ENSMUSG0000003805818
Nlrx1 / Q3TL44 / NLR family member X1 / Q86UT6*ENSMUSG0000003210916
Ciita / P79621 / MHC class II transactivator / P33076* / class II major histocompatibility complex transactivator*ENSMUSG0000002250413


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0031396 regulation of protein ubiquitination IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032687 negative regulation of interferon-alpha production IMP
 biological_processGO:0032688 negative regulation of interferon-beta production IMP
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response IMP
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IEA
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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