ENSMUSG00000074151


Mus musculus

Features
Gene ID: ENSMUSG00000074151
  
Biological name :Nlrc5
  
Synonyms : C3VPR6 / Nlrc5 / Protein NLRC5
  
Possible biological names infered from orthology : NLR family CARD domain containing 5 / Q86WI3
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 94434356
Gene end: 94527272
  
Corresponding Affymetrix probe sets: 10574098 (MoGene1.0st)   10574100 (MoGene1.0st)   10574102 (MoGene1.0st)   10574104 (MoGene1.0st)   10574133 (MoGene1.0st)   10574135 (MoGene1.0st)   10574137 (MoGene1.0st)   10574139 (MoGene1.0st)   10574141 (MoGene1.0st)   10574143 (MoGene1.0st)   10574145 (MoGene1.0st)   10574149 (MoGene1.0st)   10574151 (MoGene1.0st)   10574153 (MoGene1.0st)   10574155 (MoGene1.0st)   10574157 (MoGene1.0st)   10574159 (MoGene1.0st)   10574161 (MoGene1.0st)   10574163 (MoGene1.0st)   1437176_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138166
Ensembl peptide - ENSMUSP00000138409
Ensembl peptide - ENSMUSP00000148540
Ensembl peptide - ENSMUSP00000148677
Ensembl peptide - ENSMUSP00000138322
NCBI entrez gene - 434341     See in Manteia.
MGI - MGI:3612191
RefSeq - XM_011248428
RefSeq - NM_001033207
RefSeq - XM_006531162
RefSeq - XM_006531163
RefSeq - XM_006531165
RefSeq - XM_006531166
RefSeq Peptide - NP_001028379
swissprot - C3VPR6
swissprot - A0A1D5RLX4
swissprot - Q3U1H4
swissprot - S4R1C5
Ensembl - ENSMUSG00000074151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlrc5ENSDARG00000024631Danio rerio
 NLRC5ENSGALG00000001256Gallus gallus
 NLRC5ENSG00000140853Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ciita / P79621 / MHC class II transactivator / P33076* / class II major histocompatibility complex transactivator*ENSMUSG0000002250412
Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*ENSMUSG0000005599411
Nlrc3 / Q5DU56 / Protein NLRC3 / Q7RTR2* / NLR family CARD domain containing 3*ENSMUSG0000004987111
Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*ENSMUSG0000003805810
Nlrx1 / Q3TL44 / NLR family member X1 / Q86UT6*ENSMUSG000000321098


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0043549 regulation of kinase activity ISO
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045345 positive regulation of MHC class I biosynthetic process ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051607 defense response to virus ISS
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway ISS
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IDA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rgs2tm1.1Kjb/Rgs2tm1.1Kjb,Tg(Tek-cre/ERT2)1Arnd/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rgs2tm1.1Kjb/Rgs2tm1.1Kjb,Tg(Tek-cre/ERT2)1Arnd/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs2tm1.1Kjb/Rgs2tm1.1Kjb,Tg(Tek-cre/ERT2)1Arnd/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Pkd1b2b1585Clo/Pkd1b2b1585Clo
Genetic Background: C57BL/6J-Pkd1b2b1585Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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