ENSMUSG00000055994


Mus musculus

Features
Gene ID: ENSMUSG00000055994
  
Biological name :Nod2
  
Synonyms : Nod2 / Nucleotide-binding oligomerization domain-containing protein 2 / Q8K3Z0
  
Possible biological names infered from orthology : nucleotide binding oligomerization domain containing 2 / Q9HC29
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 88647315
Gene end: 88688474
  
Corresponding Affymetrix probe sets: 10573790 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000050538
Ensembl peptide - ENSMUSP00000105262
Ensembl peptide - ENSMUSP00000113773
NCBI entrez gene - 257632     See in Manteia.
MGI - MGI:2429397
RefSeq - XM_011248390
RefSeq - NM_145857
RefSeq - XM_006531028
RefSeq - XM_006531029
RefSeq Peptide - NP_665856
swissprot - Q80SY9
swissprot - Q8K3Z0
Ensembl - ENSMUSG00000055994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nod2ENSDARG00000010756Danio rerio
 NOD2ENSG00000167207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*ENSMUSG0000003805830
Nlrc3 / Q5DU56 / Protein NLRC3 / Q7RTR2* / NLR family CARD domain containing 3*ENSMUSG0000004987122
Nlrc5 / C3VPR6 / Protein NLRC5 / Q86WI3* / NLR family CARD domain containing 5*ENSMUSG0000007415120
Nlrx1 / Q3TL44 / NLR family member X1 / Q86UT6*ENSMUSG0000003210917
Ciita / P79621 / MHC class II transactivator / P33076* / class II major histocompatibility complex transactivator*ENSMUSG0000002250416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR018228  Deoxyribonuclease, TatD-related, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IMP
 biological_processGO:0002253 activation of immune response IMP
 biological_processGO:0002367 cytokine production involved in immune response ISS
 biological_processGO:0002374 cytokine secretion involved in immune response ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response IMP
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IMP
 biological_processGO:0002710 negative regulation of T cell mediated immunity IMP
 biological_processGO:0002732 positive regulation of dendritic cell cytokine production IEA
 biological_processGO:0002830 positive regulation of type 2 immune response ISO
 biological_processGO:0002862 negative regulation of inflammatory response to antigenic stimulus IMP
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
 biological_processGO:0006259 DNA metabolic process IEA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006963 positive regulation of antibacterial peptide biosynthetic process IDA
 biological_processGO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009595 detection of biotic stimulus TAS
 biological_processGO:0016045 detection of bacterium ISS
 biological_processGO:0030277 maintenance of gastrointestinal epithelium ISO
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032494 response to peptidoglycan IMP
 biological_processGO:0032495 response to muramyl dipeptide ISS
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032498 detection of muramyl dipeptide ISS
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032701 negative regulation of interleukin-18 production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032731 positive regulation of interleukin-1 beta production ISO
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0032740 positive regulation of interleukin-17 production ISS
 biological_processGO:0032755 positive regulation of interleukin-6 production ISO
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISO
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway IMP
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0042742 defense response to bacterium ISS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IMP
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045089 positive regulation of innate immune response IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISS
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0050871 positive regulation of B cell activation ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051259 protein complex oligomerization TAS
 biological_processGO:0051353 positive regulation of oxidoreductase activity IDA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IMP
 biological_processGO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway ISS
 biological_processGO:0071224 cellular response to peptidoglycan IMP
 biological_processGO:0071225 cellular response to muramyl dipeptide ISS
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071608 macrophage inflammatory protein-1 alpha production IMP
 biological_processGO:0071639 positive regulation of monocyte chemotactic protein-1 production IMP
 biological_processGO:0090022 regulation of neutrophil chemotaxis IMP
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response ISO
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1902523 positive regulation of protein K63-linked ubiquitination ISO
 biological_processGO:1904417 positive regulation of xenophagy IMP
 biological_processGO:2000110 negative regulation of macrophage apoptotic process IDA
 biological_processGO:2000363 positive regulation of prostaglandin-E synthase activity IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0008180 COP9 signalosome ISS
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0031982 vesicle ISS
 cellular_componentGO:0032991 protein-containing complex ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016888 endodeoxyribonuclease activity, producing 5"-phosphomonoesters IEA
 molecular_functionGO:0019899 enzyme binding ISS
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0030544 Hsp70 protein binding ISO
 molecular_functionGO:0032500 muramyl dipeptide binding ISO
 molecular_functionGO:0042834 peptidoglycan binding TAS
 molecular_functionGO:0050700 CARD domain binding ISS
 molecular_functionGO:0051879 Hsp90 protein binding ISO


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gzmatm1Simn/Gzmatm1Simn,Gzmbtm1Ley/Gzmbtm1Ley,Prf1tm1Sdz/Prf1tm1Sdz
Genetic Background: B6.Cg-Gzmatm1Simn Gzmbtm1Ley Prf1tm1Sdz

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax61Jrt/Pax6+
Genetic Background: C3.B6-Pax61Jrt

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nod1tm1Inoh/Nod1tm1Inoh,Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

Allelic Composition: Nod2tm1Daph/Nod2tm1Daph
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002467 impaired neutrophil phagocytosis "reduced ability of these leukocytes to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: involves: 129

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Pglyrp1tm1Rdz/Pglyrp1tm1Rdz,Pglyrp2tm1Rdz/Pglyrp2tm1Rdz
Genetic Background: C.129S-Pglyrp1tm1Rdz Pglyrp2tm1Rdz

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0008132 increased Peyer s patch number "greater number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Txnrd1tm1.1Ees/Txnrd1tm1.1Ees
Genetic Background: B6.129X1-Txnrd1tm1.1Ees

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nod2tm1Daph/Nod2tm1Daph
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nod1tm1Inoh/Nod1tm1Inoh,Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nod1tm1Inoh/Nod1tm1Inoh,Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax61Jrt/Pax6+
Genetic Background: C3.B6-Pax61Jrt

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nod2tm1Jhgt/Nod2tm1Jhgt
Genetic Background: B6.Cg-Nod2tm1Jhgt

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000036712 Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD / Q9NQC7* / CYLD lysine 63 deubiquitinase*  / reaction
 ENSMUSG00000026928 Card9 / A2AIV8 / Caspase recruitment domain-containing protein 9 / Q9H257* / caspase recruitment domain family member 9*  / reaction / complex
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / complex / reaction
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr