ENSDARG00000010756


Danio rerio

Features
Gene ID: ENSDARG00000010756
  
Biological name :nod2
  
Synonyms : nod2 / nucleotide-binding oligomerization domain containing 2
  
Possible biological names infered from orthology : Nucleotide-binding oligomerization domain-containing protein 2 / Q8K3Z0 / Q9HC29
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 37555568
Gene end: 37563965
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124380
NCBI entrez gene - 777696     See in Manteia.
swissprot - F8W3K2
ZFIN ID - ZDB-GENE-061108-4
Ensembl - ENSDARG00000010756
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOD2ENSG00000167207Homo sapiens
 Nod2ENSMUSG00000055994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nod1 / nucleotide-binding oligomerization domain containing 1 / Q9Y239*ENSDARG0000003630826
nlrp16 / NACHT, LRR and PYD domains-containing protein 16ENSDARG0000007767320
si:dkey-13n15.11ENSDARG0000007800220
si:ch211-149a19.3ENSDARG0000007945619
nlrc8 / NLR family CARD domain containing 8ENSDARG0000007681919
si:dkey-121n8.7ENSDARG0000009406719
si:ch211-201o1.1ENSDARG0000008868919
si:ch211-250k18.7ENSDARG0000009376119
si:ch211-214b16.4ENSDARG0000007434519
si:dkey-23k10.2ENSDARG0000009770019
si:dkey-118k5.3ENSDARG0000008773619
si:ch73-286h23.4ENSDARG0000009019318
si:dkey-14o6.1ENSDARG0000009838318
si:dkey-279j5.1ENSDARG0000010145918
si:ch211-250k18.5ENSDARG0000006874918
si:ch211-22k7.9 / si:dkey-265e15.5ENSDARG0000008887018
si:ch211-233m11.1ENSDARG0000007465318
nlrc6 / NLR family CARD domain containing 6ENSDARG0000009132018
si:dkey-261j11.2ENSDARG0000010155118
si:ch211-196h16.4ENSDARG0000009478218


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IGI
 biological_processGO:0009617 response to bacterium IDA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051607 defense response to virus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IGI
 molecular_functionGO:0050700 CARD domain binding ISS


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island neutrophil decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism viability , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSDARG00000027777 tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / Q60769* / TNF alpha induced protein 3*  / reaction
 ENSDARG00000021509 tab2 / Q5RFW2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q9NYJ8* / Q99K90* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSDARG00000062063 tab3 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSDARG00000010756 nod2 / nucleotide-binding oligomerization domain containing 2 / Q8K3Z0* / Q9HC29* / Nucleotide-binding oligomerization domain-containing protein 2 *  / reaction / complex
 ENSDARG00000060058 cylda / cylindromatosis (turban tumor syndrome), a / CYLD* / Q80TQ2* / Q9NQC7* / CYLD lysine 63 deubiquitinase* / Ubiquitin carboxyl-terminal hydrolase CYLD *  / reaction






 

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