ENSDARG00000060058


Danio rerio

Features
Gene ID: ENSDARG00000060058
  
Biological name :cylda
  
Synonyms : cylda / cylindromatosis (turban tumor syndrome), a
  
Possible biological names infered from orthology : CYLD / CYLD lysine 63 deubiquitinase / Q80TQ2 / Q9NQC7 / Ubiquitin carboxyl-terminal hydrolase CYLD
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 37514780
Gene end: 37555208
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000123913
Ensembl peptide - ENSDARP00000154149
Ensembl peptide - ENSDARP00000123696
NCBI entrez gene - 556823     See in Manteia.
RefSeq - XM_005169019
swissprot - E7FEV5
swissprot - F8W5E2
ZFIN ID - ZDB-GENE-061108-2
Ensembl - ENSDARG00000060058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYLDENSGALG00000003753Gallus gallus
 CYLDENSG00000083799Homo sapiens
 CyldENSMUSG00000036712Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyldl / cylindromatosis (turban tumor syndrome), likeENSDARG0000009015331
cyldb / cylindromatosis (turban tumor syndrome), bENSDARG0000008972430
si:cabz01101003.1ENSDARG0000010555112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0021551 central nervous system morphogenesis IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IBA
 biological_processGO:0070266 necroptotic process IBA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:1904888 cranial skeletal system development IMP
 biological_processGO:1990108 protein linear deubiquitination IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IBA
 biological_processGO:2001242 regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity IDA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary decreased thickness , abnormal
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 ZFA:0000128 midbrain midbrain increased size , abnormal
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 ZFA:0001114 head head malformed , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage shape , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction
 ENSDARG00000054456 clip3 / CAP-GLY domain containing linker protein 3 / B9EHT4* / Q96DZ5* / AC006030.1*  / reaction / complex
 ENSDARG00000010756 nod2 / nucleotide-binding oligomerization domain containing 2 / Q8K3Z0* / Q9HC29* / Nucleotide-binding oligomerization domain-containing protein 2 *  / reaction
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSDARG00000030173 traf2a / Tnf receptor-associated factor 2a / TRAF2* / P39429* / Q12933* / TNF receptor associated factor 2*  / complex






 

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