ENSGALG00000003753


Gallus gallus

Features
Gene ID: ENSGALG00000003753
  
Biological name :CYLD
  
Synonyms : CYLD / CYLD lysine 63 deubiquitinase
  
Possible biological names infered from orthology : Q80TQ2 / Q9NQC7 / Ubiquitin carboxyl-terminal hydrolase CYLD
  
Species: Gallus gallus
  
Chr. number: 11
Strand: -1
Band:
Gene start: 6275128
Gene end: 6297360
  
Corresponding Affymetrix probe sets: Gga.10406.1.S1_s_at (Chicken Array)   Gga.10406.2.S1_s_at (Chicken Array)   GgaAffx.11335.1.S1_at (Chicken Array)   GgaAffx.25968.1.S1_at (Chicken Array)   GgaAffx.6228.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016104
NCBI entrez gene - 415725     See in Manteia.
RefSeq - XM_004944175
RefSeq - XM_414091
RefSeq - XM_004944176
RefSeq - XM_015292398
swissprot - F1NH67
Ensembl - ENSGALG00000003753
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyldaENSDARG00000060058Danio rerio
 CYLDENSG00000083799Homo sapiens
 CyldENSMUSG00000036712Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000004623530


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045577 regulation of B cell differentiation IEA
 biological_processGO:0045581 negative regulation of T cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IEA
 biological_processGO:0070266 necroptotic process IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1901026 ripoptosome assembly involved in necroptotic process IEA
 biological_processGO:1902017 regulation of cilium assembly IEA
 biological_processGO:1903829 positive regulation of cellular protein localization IEA
 biological_processGO:1990108 protein linear deubiquitination IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001242 regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0097542 ciliary tip IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity IEA
 molecular_functionGO:0070064 proline-rich region binding IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / complex






 

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