ENSMUSG00000036712


Mus musculus

Features
Gene ID: ENSMUSG00000036712
  
Biological name :Cyld
  
Synonyms : Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD
  
Possible biological names infered from orthology : CYLD lysine 63 deubiquitinase / Q9NQC7
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 88697028
Gene end: 88751945
  
Corresponding Affymetrix probe sets: 10573803 (MoGene1.0st)   1429201_at (Mouse Genome 430 2.0 Array)   1429617_at (Mouse Genome 430 2.0 Array)   1429618_at (Mouse Genome 430 2.0 Array)   1445213_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148037
Ensembl peptide - ENSMUSP00000039834
Ensembl peptide - ENSMUSP00000096119
Ensembl peptide - ENSMUSP00000147654
Ensembl peptide - ENSMUSP00000147904
Ensembl peptide - ENSMUSP00000105254
Ensembl peptide - ENSMUSP00000147426
NCBI entrez gene - 74256     See in Manteia.
MGI - MGI:1921506
RefSeq - XM_011248525
RefSeq - XM_006531414
RefSeq - XM_006531415
RefSeq - XM_006531416
RefSeq - XM_006531417
RefSeq - XM_006531419
RefSeq - XM_006531418
RefSeq - XM_006531420
RefSeq - XM_011248523
RefSeq - XM_011248524
RefSeq - NM_001128170
RefSeq - NM_001128171
RefSeq - NM_001276279
RefSeq - NM_173369
RefSeq - XM_017312989
RefSeq Peptide - NP_001121643
RefSeq Peptide - NP_001121642
RefSeq Peptide - NP_001263208
RefSeq Peptide - NP_775545
swissprot - Q80TQ2
swissprot - A0A1B0GSE5
swissprot - Z4YJJ5
Ensembl - ENSMUSG00000036712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyldaENSDARG00000060058Danio rerio
 CYLDENSGALG00000003753Gallus gallus
 CYLDENSG00000083799Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR036859  CAP Gly-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007346 regulation of mitotic cell cycle ISO
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IBA
 biological_processGO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
 biological_processGO:0043393 regulation of protein binding IDA
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045577 regulation of B cell differentiation IMP
 biological_processGO:0045581 negative regulation of T cell differentiation IDA
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050856 regulation of T cell receptor signaling pathway ISO
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0070266 necroptotic process IGI
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization ISO
 biological_processGO:0070536 protein K63-linked deubiquitination ISO
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISS
 biological_processGO:1901026 ripoptosome assembly involved in necroptotic process IMP
 biological_processGO:1902017 regulation of cilium assembly IMP
 biological_processGO:1903829 positive regulation of cellular protein localization IDA
 biological_processGO:1990108 protein linear deubiquitination ISS
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IBA
 biological_processGO:2001242 regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097542 ciliary tip IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity ISO
 molecular_functionGO:0070064 proline-rich region binding ISO
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity IDA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000199 abnormal circulating albumin level "aberrant concentration in the blood of this most abundant of the plasma proteins " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Ikbkgtm1.1Mpa/Y,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Cyldtm1.1Mpa Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Cyldtm1Ref/Cyld+
Genetic Background: B6.129-Cyldtm1Ref

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0002327 abnormal respiratory function "anomaly in any measure of the processes involved in respiration" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pycardtm1Flv/Pycardtm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Pycardtm1Flv

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Ikbkgtm1.1Mpa/Y,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Cyldtm1.1Mpa Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum

 MP:0003282 gastric ulcer "a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Itgb1tm1Mll/Itgb1tm1Mll,Tg(Wap-cre)1Gsc/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008171 abnormal mature B cell morphology "any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Awai/Cyldtm1.1Awai
Genetic Background: Not Specified

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itga3tm1Son/Itga3tm1Son,Tg(NPHS2-cre)295Lbh/0
Genetic Background: Not Specified

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

 MP:0009582 abnormal keratinocyte proliferation "anomaly in the ability of the epidermal cells that produce keratin to undergo expansion by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Spi1tm1.3Dgt/Spi1tm1.3Dgt
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pycardtm1Flv/Pycardtm1Flv,Slc11a1s/Slc11a1s
Genetic Background: B6.129S5-Pycardtm1Flv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Il1rntm1.1Cga/Il1rntm1.1Cga,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: D1.Cg-Il1rntm1.1Cga Lyz2tm1(cre)Ifo

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Cyldtm1Scs/Cyldtm1Scs,Ripk3tm2Vmd/Ripk3tm2Vmd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Cyldtm1.1Mpa/Cyldtm1.1Mpa,Faddtm1Mpa/Faddtm1Mpa,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Faddtm1Mpa Cyldtm1.1Mpa Tg(Vil1-cre)997Gum

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / reaction
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex






 

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