ENSMUSG00000026942


Mus musculus

Features
Gene ID: ENSMUSG00000026942
  
Biological name :Traf2
  
Synonyms : P39429 / TNF receptor-associated factor 2 / Traf2
  
Possible biological names infered from orthology : Q12933
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25517982
Gene end: 25546940
  
Corresponding Affymetrix probe sets: 10480760 (MoGene1.0st)   1451233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028311
Ensembl peptide - ENSMUSP00000109872
NCBI entrez gene - 22030     See in Manteia.
MGI - MGI:101835
RefSeq - XM_006497850
RefSeq - NM_001290413
RefSeq - NM_009422
RefSeq - XM_006497849
RefSeq Peptide - NP_001277342
RefSeq Peptide - NP_033448
swissprot - P39429
swissprot - Q3U8L1
Ensembl - ENSMUSG00000026942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf2aENSDARG00000030173Danio rerio
 unm_sa808ENSDARG00000078378Danio rerio
 TRAF2ENSGALG00000042838Gallus gallus
 TRAF2ENSG00000127191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*ENSMUSG0000002127735
Traf5 / TNF receptor-associated factor 5 / O00463*ENSMUSG0000002663733
Traf1 / P39428 / TNF receptor-associated factor 1 / Q13077*ENSMUSG0000002687531
Traf4 / Q61382 / TNF receptor-associated factor 4 / Q9BUZ4*ENSMUSG0000001738627
Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*ENSMUSG0000002716426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027133  TNF receptor-associated factor 2
 IPR032070  TNF receptor-associated factor, BIRC3 binding domain
 IPR037305  TNF receptor-associated factor 2, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002726 positive regulation of T cell cytokine production IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030163 protein catabolic process IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISS
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IDA
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0051023 regulation of immunoglobulin secretion IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051865 protein autoubiquitination ISO
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0071732 cellular response to nitric oxide IMP
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 biological_processGO:0097300 programmed necrotic cell death IMP
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:1903721 positive regulation of I-kappaB phosphorylation IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 cellular_componentGO:0035631 CD40 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097057 TRAF2-GSTP1 complex IEA
 cellular_componentGO:1990597 AIP1-IRE1 complex IPI
 cellular_componentGO:1990604 IRE1-TRAF2-ASK1 complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding ISO
 molecular_functionGO:0005174 CD40 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046625 sphingolipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
Dimerization of procaspase-8
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008175 absent follicular B cells "absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13btm1Msc,Traf2tm1Rbr/Traf2tm1Rbr
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Aqp2tm1.1Ask/Aqp2tm1.1Ask
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005824 Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000023905 Q9CR75 / Tnfrsf12a / Tumor necrosis factor receptor superfamily member 12A / Q9NP84* / TNF receptor superfamily member 12A*  / reaction / complex
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000024399 Ltb / P41155 / Lymphotoxin-beta / Q06643*  / complex / reaction
 ENSMUSG00000024402 Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*  / complex / reaction
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSMUSG00000032612 Usp4 / P35123 / ubiquitin specific peptidase 4 (proto-oncogene) / Q13107* / ubiquitin specific peptidase 4*  / reaction / complex
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / reaction / complex
 ENSMUSG00000028599 P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSMUSG00000030339 Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000043411 Usp48 / Q3V0C5 / ubiquitin specific peptidase 48 / Q86UV5*  / complex
 ENSMUSG00000036712 Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD / Q9NQC7* / CYLD lysine 63 deubiquitinase*  / complex
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / reaction / complex
 ENSMUSG00000017652 Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000022015 O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*  / reaction / complex
 ENSMUSG00000031132 Cd40lg / P27548 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P29965* / CD40 ligand*  / reaction / complex
 ENSMUSG00000026321 O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*  / reaction / complex
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / complex / reaction
 ENSMUSG00000068105 Q9D8D0 / Tnfrsf13c / tumor necrosis factor receptor superfamily, member 13c / Q96RJ3* / TNF receptor superfamily member 13C*  / complex / reaction
 ENSMUSG00000097328 O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...  / reaction / complex






 

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