ENSMUSG00000026875


Mus musculus

Features
Gene ID: ENSMUSG00000026875
  
Biological name :Traf1
  
Synonyms : P39428 / TNF receptor-associated factor 1 / Traf1
  
Possible biological names infered from orthology : Q13077
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 34941750
Gene end: 34961772
  
Corresponding Affymetrix probe sets: 10481949 (MoGene1.0st)   1423602_at (Mouse Genome 430 2.0 Array)   1445452_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028234
Ensembl peptide - ENSMUSP00000108687
Ensembl peptide - ENSMUSP00000130759
Ensembl peptide - ENSMUSP00000144189
NCBI entrez gene - 22029     See in Manteia.
MGI - MGI:101836
RefSeq - XM_017317129
RefSeq - NM_001326601
RefSeq - NM_009421
RefSeq - XM_011239052
RefSeq - XM_011239053
RefSeq - XM_011239054
RefSeq - XM_011239055
RefSeq - XM_011239050
RefSeq - XM_011239051
RefSeq Peptide - NP_001313530
RefSeq Peptide - NP_033447
swissprot - P39428
swissprot - A0A0J9YUH9
Ensembl - ENSMUSG00000026875
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf1ENSDARG00000069482Danio rerio
 TRAF1ENSGALG00000001583Gallus gallus
 TRAF1ENSG00000056558Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*ENSMUSG0000002694239
Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*ENSMUSG0000002127733
Traf5 / TNF receptor-associated factor 5 / O00463*ENSMUSG0000002663731
Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*ENSMUSG0000002716422
Traf4 / Q61382 / TNF receptor-associated factor 4 / Q9BUZ4*ENSMUSG0000001738622


Protein motifs (from Interpro)
Interpro ID Name
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR027136  TNF receptor-associated factor 1
 IPR032070  TNF receptor-associated factor, BIRC3 binding domain
 IPR037306  TNF receptor-associated factor 1, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:2001236 regulation of extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0031996 thioesterase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf2tm1Mak/Traf2tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr