ENSMUSG00000026637


Mus musculus

Features
Gene ID: ENSMUSG00000026637
  
Biological name :Traf5
  
Synonyms : TNF receptor-associated factor 5 / Traf5
  
Possible biological names infered from orthology : O00463
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 191997205
Gene end: 192092559
  
Corresponding Affymetrix probe sets: 10361139 (MoGene1.0st)   1448861_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082710
Ensembl peptide - ENSMUSP00000141584
Ensembl peptide - ENSMUSP00000141931
MGI - MGI:107548
swissprot - A0A0A6YWK3
swissprot - A0A0A6YXC4
swissprot - E9QMA6
Ensembl - ENSMUSG00000026637
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf5ENSDARG00000017240Danio rerio
 TRAF5ENSGALG00000009864Gallus gallus
 TRAF5ENSG00000082512Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*ENSMUSG0000002127742
Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*ENSMUSG0000002694230
Traf4 / Q61382 / TNF receptor-associated factor 4 / Q9BUZ4*ENSMUSG0000001738625
Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*ENSMUSG0000002716424
Traf1 / P39428 / TNF receptor-associated factor 1 / Q13077*ENSMUSG0000002687523


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027130  TNF receptor-associated factor 5
 IPR037308  TNF receptor-associated factor 5, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0005153 abnormal B cell proliferation "change from the norm in the ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otop1mlh/Otop1mlh
Genetic Background: involves: BALB/cJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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