ENSMUSG00000017386


Mus musculus

Features
Gene ID: ENSMUSG00000017386
  
Biological name :Traf4
  
Synonyms : Q61382 / TNF receptor-associated factor 4 / Traf4
  
Possible biological names infered from orthology : Q9BUZ4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 78158499
Gene end: 78165589
  
Corresponding Affymetrix probe sets: 10388749 (MoGene1.0st)   1416571_at (Mouse Genome 430 2.0 Array)   1460642_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017530
NCBI entrez gene - 22032     See in Manteia.
MGI - MGI:1202880
RefSeq - NM_009423
RefSeq - XM_006533156
RefSeq Peptide - NP_033449
swissprot - Q61382
Ensembl - ENSMUSG00000017386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf4aENSDARG00000003963Danio rerio
 TRAF4ENSGALG00000003987Gallus gallus
 TRAF4ENSG00000076604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Traf5 / TNF receptor-associated factor 5 / O00463*ENSMUSG0000002663730
Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*ENSMUSG0000002694229
Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*ENSMUSG0000002127728
Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*ENSMUSG0000002716423
Traf1 / P39428 / TNF receptor-associated factor 1 / Q13077*ENSMUSG0000002687520


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027138  TNF receptor-associated factor 4
 IPR037307  TNF receptor-associated factor 4, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0030323 respiratory tube development IMP
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050699 WW domain binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv5tm1.2Xsun/Etv5tm1.2Xsun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

Allelic Composition: Traf4tm2Lind/Traf4tm2Lind
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

Allelic Composition: Traf4tm2Lind/Traf4tm2Lind
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0001950 abnormal respiratory sounds "anomalous noises heard over any part of the respiratory tract" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv5tm1.2Xsun/Etv5tm1.2Xsun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv5tm1.2Xsun/Etv5tm1.2Xsun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0003051 curly tail "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

Allelic Composition: Traf4tm2Lind/Traf4tm2Lind
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0004173 abnormal intervertebral disk morphology "malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0004549 small trachea "reduced size of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0004552 fused tracheal cartilage rings "fusion of the 16-20 incomplete rings of hyaline cartilage that form the skeleton of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0005297 spina bifida occulta "common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb3msp1/Erbb3msp1,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0010883 trachea stenosis "abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

Allelic Composition: Traf4tm2Lind/Traf4tm2Lind
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Traf4m1Pav/Traf4m1Pav,Sox10tm1Weg/Sox10+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0012547 spina bifida cystica "spinal bifida in which a hernial cyst containing meninges (meningocele), spinal cord (myelocele), or both (myelomeningocele) protrudes through a congenital cleft in the vertebral column; the protruding sac is encased in a layer of skin or a fine membrane that readily ruptures, causing leakage of cerebrospinal fluid and an increased risk of meningeal infection" [MGI:anna]
Show

Allelic Composition: Traf4tm1Mrio/Traf4tm1Mrio
Genetic Background: involves: 129X1/SvJ

 MP:0013752 stridor "a high-pitched breath sound resulting from turbulent air flow in the larynx or lower in the bronchial tree; it should not to be confused with stertor which is a noise originating in the pharynx; stridor is a physical sign which is caused by a narrowed or obstructed airway; it can be inspiratory, expiratory or biphasic, although it is usually heard during inspiration" [http://en.wikipedia.org/wiki/Stridor, MGI:Anna]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

Allelic Composition: Traf4tm2Lind/Traf4tm2Lind
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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