ENSG00000056558


Homo sapiens

Features
Gene ID: ENSG00000056558
  
Biological name :TRAF1
  
Synonyms : Q13077 / TNF receptor associated factor 1 / TRAF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.2
Gene start: 120902393
Gene end: 120929173
  
Corresponding Affymetrix probe sets: 205599_at (Human Genome U133 Plus 2.0 Array)   235116_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362994
Ensembl peptide - ENSP00000438583
Ensembl peptide - ENSP00000443183
NCBI entrez gene - 7185     See in Manteia.
OMIM - 601711
RefSeq - NM_001190947
RefSeq - NM_001190945
RefSeq - NM_005658
RefSeq Peptide - NP_001177874
RefSeq Peptide - NP_001177876
RefSeq Peptide - NP_005649
swissprot - Q13077
Ensembl - ENSG00000056558
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf1ENSDARG00000069482Danio rerio
 TRAF1ENSGALG00000001583Gallus gallus
 Traf1ENSMUSG00000026875Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF2 / Q12933 / TNF receptor associated factor 2ENSG0000012719138
TRAF3 / Q13114 / TNF receptor associated factor 3ENSG0000013132332
TRAF5 / O00463 / TNF receptor associated factor 5ENSG0000008251231
TRAF4 / Q9BUZ4 / TNF receptor associated factor 4ENSG0000007660422
TRAF6 / Q9Y4K3 / TNF receptor associated factor 6ENSG0000017510420


Protein motifs (from Interpro)
Interpro ID Name
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR027136  TNF receptor-associated factor 1
 IPR032070  TNF receptor-associated factor, BIRC3 binding domain
 IPR037306  TNF receptor-associated factor 1, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:2001236 regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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