ENSG00000131323


Homo sapiens

Features
Gene ID: ENSG00000131323
  
Biological name :TRAF3
  
Synonyms : Q13114 / TNF receptor associated factor 3 / TRAF3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.32
Gene start: 102777476
Gene end: 102911500
  
Corresponding Affymetrix probe sets: 208315_x_at (Human Genome U133 Plus 2.0 Array)   221571_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453623
Ensembl peptide - ENSP00000453032
Ensembl peptide - ENSP00000454207
Ensembl peptide - ENSP00000328003
Ensembl peptide - ENSP00000332468
Ensembl peptide - ENSP00000376500
Ensembl peptide - ENSP00000445998
Ensembl peptide - ENSP00000453031
NCBI entrez gene - 7187     See in Manteia.
OMIM - 601896
RefSeq - XM_017021620
RefSeq - NM_003300
RefSeq - NM_145725
RefSeq - NM_145726
RefSeq - XM_011537116
RefSeq - XM_011537117
RefSeq - XM_011537118
RefSeq - XM_017021617
RefSeq - XM_017021618
RefSeq - XM_017021619
RefSeq - NM_001199427
RefSeq Peptide - NP_003291
RefSeq Peptide - NP_663777
RefSeq Peptide - NP_663778
RefSeq Peptide - NP_001186356
swissprot - H0YL25
swissprot - Q13114
swissprot - H0YL26
swissprot - H0YMI8
swissprot - A6NHG8
Ensembl - ENSG00000131323
  
Related genetic diseases (OMIM): 614849 - {?Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 5}, 614849
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf3ENSDARG00000022000Danio rerio
 TRAF3ENSGALG00000011389Gallus gallus
 Traf3ENSMUSG00000021277Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRAF5 / O00463 / TNF receptor associated factor 5ENSG0000008251241
TRAF2 / Q12933 / TNF receptor associated factor 2ENSG0000012719131
TRAF1 / Q13077 / TNF receptor associated factor 1ENSG0000005655824
TRAF4 / Q9BUZ4 / TNF receptor associated factor 4ENSG0000007660423
TRAF6 / Q9Y4K3 / TNF receptor associated factor 6ENSG0000017510422


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027128  TNF receptor-associated factor 3
 IPR037304  TRAF3, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0002224 toll-like receptor signaling pathway ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030162 regulation of proteolysis IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032648 regulation of interferon-beta production ISS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0035631 CD40 receptor complex ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031996 thioesterase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TRAF3 deficiency - HSE
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000068308 OTUD5 / Q96G74 / OTU deubiquitinase 5  / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / reaction / complex
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / reaction / complex
 ENSG00000159958 Q96RJ3 / TNFRSF13C / TNF receptor superfamily member 13C  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / reaction / complex
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / reaction / complex
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / reaction / complex
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / reaction / complex
 ENSG00000102245 CD40LG / P29965 / CD40 ligand  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000120659 O14788 / TNFSF11 / TNF superfamily member 11  / reaction / complex
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / reaction
 ENSG00000141655 Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11a  / reaction / complex
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / reaction / complex
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex
 ENSG00000101017 CD40 / P25942 / CD40 molecule  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex
 ENSG00000102524 Q9Y275 / TNFSF13B / TNF superfamily member 13b  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction / complex
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / reaction / complex
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / reaction / complex






 

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