ENSG00000052723


Homo sapiens

Features
Gene ID: ENSG00000052723
  
Biological name :SIKE1
  
Synonyms : Q9BRV8 / SIKE1 / suppressor of IKBKE 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.2
Gene start: 114769479
Gene end: 114780685
  
Corresponding Affymetrix probe sets: 204665_at (Human Genome U133 Plus 2.0 Array)   204666_s_at (Human Genome U133 Plus 2.0 Array)   221705_s_at (Human Genome U133 Plus 2.0 Array)   228026_at (Human Genome U133 Plus 2.0 Array)   235294_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000060969
Ensembl peptide - ENSP00000358541
NCBI entrez gene - 80143     See in Manteia.
OMIM - 611656
RefSeq - NM_001102396
RefSeq - NM_025073
RefSeq Peptide - NP_001095866
RefSeq Peptide - NP_079349
swissprot - Q9BRV8
Ensembl - ENSG00000052723
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 im:6912630ENSDARG00000102199Danio rerio
 SIKE1ENSGALG00000002147Gallus gallus
 Sike1ENSMUSG00000027854Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NVK5 / FGFR1OP2 / FGFR1 oncogene partner 2ENSG0000011179050


Protein motifs (from Interpro)
Interpro ID Name
 IPR008555  SIKE family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / reaction
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / complex






 

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