ENSG00000136560


Homo sapiens

Features
Gene ID: ENSG00000136560
  
Biological name :TANK
  
Synonyms : Q92844 / TANK / TRAF family member associated NFKB activator
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q24.2
Gene start: 161136908
Gene end: 161236221
  
Corresponding Affymetrix probe sets: 207616_s_at (Human Genome U133 Plus 2.0 Array)   209451_at (Human Genome U133 Plus 2.0 Array)   210458_s_at (Human Genome U133 Plus 2.0 Array)   243376_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385487
Ensembl peptide - ENSP00000384492
Ensembl peptide - ENSP00000385983
Ensembl peptide - ENSP00000412622
Ensembl peptide - ENSP00000412556
Ensembl peptide - ENSP00000411041
Ensembl peptide - ENSP00000410259
Ensembl peptide - ENSP00000399934
Ensembl peptide - ENSP00000398157
Ensembl peptide - ENSP00000392776
Ensembl peptide - ENSP00000388930
Ensembl peptide - ENSP00000387439
Ensembl peptide - ENSP00000259075
Ensembl peptide - ENSP00000376505
Ensembl peptide - ENSP00000384235
NCBI entrez gene - 10010     See in Manteia.
OMIM - 603893
RefSeq - XM_017003097
RefSeq - NM_001199135
RefSeq - NM_004180
RefSeq - NM_133484
RefSeq - XM_005246207
RefSeq - XM_017003093
RefSeq - XM_017003094
RefSeq - XM_017003095
RefSeq - XM_017003096
RefSeq Peptide - NP_004171
RefSeq Peptide - NP_597841
RefSeq Peptide - NP_001186064
swissprot - Q92844
swissprot - E7EM55
swissprot - E9PEK1
swissprot - E7EWR8
swissprot - E7EW82
swissprot - E7EVA2
swissprot - E7EV32
swissprot - E7ERM9
swissprot - E7EQA9
swissprot - E7EMT6
swissprot - E7ENY2
swissprot - H7BZ28
swissprot - H7C3L4
Ensembl - ENSG00000136560
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tankENSDARG00000067723Danio rerio
 TANKENSGALG00000011131Gallus gallus
 TankENSMUSG00000064289Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024581  Tbk1/Ikki binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:1903003 positive regulation of protein deubiquitination IMP
 biological_processGO:2000158 positive regulation of ubiquitin-specific protease activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0035800 deubiquitinase activator activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TICAM1-dependent activation of IRF3/IRF7
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / reaction / complex
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / reaction / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / reaction / complex
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000052723 SIKE1 / Q9BRV8 / suppressor of IKBKE 1  / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / reaction / complex
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / reaction / complex
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / reaction / complex






 

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