ENSG00000232810


Homo sapiens

Features
Gene ID: ENSG00000232810
  
Biological name :TNF
  
Synonyms : P01375 / TNF / tumor necrosis factor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.33
Gene start: 31575567
Gene end: 31578336
  
Corresponding Affymetrix probe sets: 207113_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398698
NCBI entrez gene - 7124     See in Manteia.
OMIM - 191160
RefSeq - NM_000594
RefSeq Peptide - NP_000585
swissprot - P01375
swissprot - Q5STB3
Ensembl - ENSG00000232810
  
Related genetic diseases (OMIM): 157300 - {Migraine without aura, susceptibility to}, 157300
  191160 - {Dementia, vascular, susceptibility to}
  600807 - {Asthma, susceptibility to}, 600807
  611162 - {Malaria, cerebral, susceptibility to}, 611162
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaENSDARG00000009511Danio rerio
 tnfbENSDARG00000013598Danio rerio
 TnfENSMUSG00000024401Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LTA / P01374 / lymphotoxin alphaENSG0000022697927
O95150 / TNFSF15 / TNF superfamily member 15ENSG0000018163426
FASLG / P48023 / Fas ligandENSG0000011756022
O43557 / TNFSF14 / TNF superfamily member 14ENSG0000012573522


Protein motifs (from Interpro)
Interpro ID Name
 IPR002959  Tumour necrosis factor alpha
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IDA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0000185 activation of MAPKKK activity IDA
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001819 positive regulation of cytokine production IDA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0002439 chronic inflammatory response to antigenic stimulus IMP
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IDA
 biological_processGO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus IEA
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0009651 response to salt stress TAS
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0010888 negative regulation of lipid storage NAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0030730 sequestering of triglyceride IDA
 biological_processGO:0030866 cortical actin cytoskeleton organization IDA
 biological_processGO:0031334 positive regulation of protein complex assembly IDA
 biological_processGO:0031622 positive regulation of fever generation IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032715 negative regulation of interleukin-6 production IDA
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IMP
 biological_processGO:0032800 receptor biosynthetic process IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IDA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IDA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043068 positive regulation of programmed cell death IDA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043242 negative regulation of protein complex disassembly IDA
 biological_processGO:0043243 positive regulation of protein complex disassembly IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IDA
 biological_processGO:0045123 cellular extravasation IEA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation NAS
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045994 positive regulation of translational initiation by iron IEA
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048566 embryonic digestive tract development IEP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050708 regulation of protein secretion IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050796 regulation of insulin secretion IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0050901 leukocyte tethering or rolling IDA
 biological_processGO:0050995 negative regulation of lipid catabolic process IDA
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051222 positive regulation of protein transport IDA
 biological_processGO:0051384 response to glucocorticoid IDA
 biological_processGO:0051798 positive regulation of hair follicle development IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060557 positive regulation of vitamin D biosynthetic process IDA
 biological_processGO:0060559 positive regulation of calcidiol 1-monooxygenase activity IDA
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IEA
 biological_processGO:0060693 regulation of branching involved in salivary gland morphogenesis IEA
 biological_processGO:0061048 negative regulation of branching involved in lung morphogenesis IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade NAS
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071316 cellular response to nicotine IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071550 death-inducing signaling complex assembly TAS
 biological_processGO:0071677 positive regulation of mononuclear cell migration NAS
 biological_processGO:0071803 positive regulation of podosome assembly IDA
 biological_processGO:0072577 endothelial cell apoptotic process IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:1901671 positive regulation of superoxide dismutase activity IDA
 biological_processGO:1903140 regulation of establishment of endothelial barrier IDA
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IDA
 biological_processGO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell IDA
 biological_processGO:2000010 positive regulation of protein localization to cell surface IDA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process TAS
 biological_processGO:2000334 positive regulation of blood microparticle formation IDA
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
Transcriptional regulation of white adipocyte differentiation
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000035681 NSMAF / Q92636 / neutral sphingomyelinase activation associated factor  / complex / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / reaction / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex
 ENSG00000151694 ADAM17 / P78536 / ADAM metallopeptidase domain 17  / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / complex / reaction
 ENSG00000204628 RACK1 / P63244 / receptor for activated C kinase 1  / complex / reaction
 ENSG00000135587 SMPD2 / O60906 / sphingomyelin phosphodiesterase 2  / reaction / complex
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction
 ENSG00000156735 BAG4 / O95429 / BCL2 associated athanogene 4  / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex
 ENSG00000103056 SMPD3 / Q9NY59 / sphingomyelin phosphodiesterase 3  / reaction / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000110514 MADD / Q8WXG6 / MAP kinase activating death domain  / reaction / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / reaction / complex






 

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