ENSG00000102871


Homo sapiens

Features
Gene ID: ENSG00000102871
  
Biological name :TRADD
  
Synonyms : Q15628 / TNFRSF1A associated via death domain / TRADD
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 67154180
Gene end: 67160298
  
Corresponding Affymetrix probe sets: 1729_at (Human Genome U133 Plus 2.0 Array)   205641_s_at (Human Genome U133 Plus 2.0 Array)   213443_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341268
Ensembl peptide - ENSP00000462591
NCBI entrez gene - 8717     See in Manteia.
OMIM - 603500
RefSeq - XM_017023815
RefSeq - NM_001323552
RefSeq - NM_003789
RefSeq - XM_005256213
RefSeq Peptide - NP_001310481
RefSeq Peptide - NP_003780
swissprot - Q15628
Ensembl - ENSG00000102871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traddENSDARG00000036057Danio rerio
 TRADDENSGALG00000003195Gallus gallus
 TraddENSMUSG00000031887Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR009095  TRADD, N-terminal
 IPR011029  Death-like domain superfamily
 IPR035712  TRADD
 IPR036729  TRADD, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051798 positive regulation of hair follicle development IEA
 biological_processGO:0060544 regulation of necroptotic process TAS
 biological_processGO:0071550 death-inducing signaling complex assembly TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway TAS
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0031264 death-inducing signaling complex TAS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0060090 molecular adaptor activity IPI
 molecular_functionGO:0070513 death domain binding IPI


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / reaction / complex
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex / reaction
 ENSG00000003402 CFLAR / O15519 / CASP8 and FADD like apoptosis regulator  / complex / reaction
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / reaction / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / reaction / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / complex / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / reaction / complex






 

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