ENSMUSG00000031887


Mus musculus

Features
Gene ID: ENSMUSG00000031887
  
Biological name :Tradd
  
Synonyms : Q3U0V2 / TNFRSF1A-associated via death domain / Tradd
  
Possible biological names infered from orthology : Q15628
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 105258286
Gene end: 105264609
  
Corresponding Affymetrix probe sets: 10581181 (MoGene1.0st)   1429117_at (Mouse Genome 430 2.0 Array)   1439910_a_at (Mouse Genome 430 2.0 Array)   1452622_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034359
Ensembl peptide - ENSMUSP00000119174
NCBI entrez gene - 71609     See in Manteia.
MGI - MGI:109200
RefSeq - NM_001033161
RefSeq Peptide - NP_001028333
swissprot - D6RCI0
swissprot - B2RRZ7
swissprot - Q3U0V2
Ensembl - ENSMUSG00000031887
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traddENSDARG00000036057Danio rerio
 TRADDENSGALG00000003195Gallus gallus
 TRADDENSG00000102871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR009095  TRADD, N-terminal
 IPR011029  Death-like domain superfamily
 IPR035712  TRADD
 IPR036729  TRADD, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051798 positive regulation of hair follicle development IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0060090 molecular adaptor activity ISO
 molecular_functionGO:0070513 death domain binding ISO


Pathways (from Reactome)
Pathway description
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Dimerization of procaspase-8
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glipr1tm1Tt/Glipr1tm1Tt,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Glipr1tm1Tt/Glipr1tm1Tt,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glipr1tm1Tt/Glipr1tm1Tt,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Traddtm1.1Mak/Tradd+
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)

 MP:0008473 abnormal spleen follicular dendritic cell network "any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Glipr1tm1Tt/Glipr1tm1Tt,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Traddtm1.1Mpa/Traddtm1.1Mpa
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Glipr1tm1Tt/Glipr1tm1Tt,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Glipr1tm1Tt/Glipr1tm1Tt,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Traddtm1.1Zgl/Traddtm1.1Zgl
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / complex / reaction
 ENSMUSG00000026031 Cflar / O35732 / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apoptosis regulator subunit p12 / O15519* / CASP8 and FADD l...  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000031887 Tradd / Q3U0V2 / TNFRSF1A-associated via death domain / Q15628*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / reaction / complex






 

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