ENSG00000137275


Homo sapiens

Features
Gene ID: ENSG00000137275
  
Biological name :RIPK1
  
Synonyms : Q13546 / receptor interacting serine/threonine kinase 1 / RIPK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p25.2
Gene start: 3063991
Gene end: 3115187
  
Corresponding Affymetrix probe sets: 209941_at (Human Genome U133 Plus 2.0 Array)   226551_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259808
Ensembl peptide - ENSP00000369773
NCBI entrez gene - 8737     See in Manteia.
RefSeq - NM_003804
RefSeq - XM_017011403
RefSeq - NM_001317061
RefSeq - NM_001354930
RefSeq - XM_005249457
RefSeq Peptide - NP_001341859
RefSeq Peptide - NP_003795
RefSeq Peptide - NP_001303990
swissprot - Q13546
swissprot - A0A024QZU0
Ensembl - ENSG00000137275
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ripk1lENSDARG00000006677Danio rerio
 RIPK1ENSGALG00000012827Gallus gallus
 Ripk1ENSMUSG00000021408Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RIPK4 / P57078 / receptor interacting serine/threonine kinase 4ENSG0000018342121
ANKK1 / Q8NFD2 / ankyrin repeat and kinase domain containing 1ENSG0000017020920
RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3ENSG0000012946517
RIPK2 / O43353 / receptor interacting serine/threonine kinase 2ENSG0000010431217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR025735  RHIM domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0010940 positive regulation of necrotic cell death IMP
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IC
 biological_processGO:0034138 toll-like receptor 3 signaling pathway TAS
 biological_processGO:0034612 response to tumor necrosis factor IMP
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0036289 peptidyl-serine autophosphorylation IDA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043068 positive regulation of programmed cell death IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0044257 cellular protein catabolic process IDA
 biological_processGO:0045651 positive regulation of macrophage differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051291 protein heterooligomerization IMP
 biological_processGO:0060544 regulation of necroptotic process TAS
 biological_processGO:0060545 positive regulation of necroptotic process IMP
 biological_processGO:0070231 T cell apoptotic process ISS
 biological_processGO:0070266 necroptotic process IMP
 biological_processGO:0070926 regulation of ATP:ADP antiporter activity IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071550 death-inducing signaling complex assembly TAS
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
 biological_processGO:0097343 ripoptosome assembly IMP
 biological_processGO:0097527 necroptotic signaling pathway IMP
 biological_processGO:1901026 ripoptosome assembly involved in necroptotic process IBA
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1905206 positive regulation of hydrogen peroxide-induced cell death IMP
 biological_processGO:1990000 amyloid fibril formation IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process TAS
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031264 death-inducing signaling complex IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097342 ripoptosome IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005123 death receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0070513 death domain binding IPI


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Ub-specific processing proteases
Ovarian tumor domain proteases
Dimerization of procaspase-8
TNF signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / - / complex / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / reaction / complex
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex
 ENSG00000124256 ZBP1 / Q9H171 / Z-DNA binding protein 1  / reaction / complex
 ENSG00000118503 P21580 / TNFAIP3 / TNF alpha induced protein 3  / complex
 ENSG00000003400 CASP10 / Q92851 / caspase 10  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction / complex
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / reaction / complex
 ENSG00000003402 CFLAR / O15519 / CASP8 and FADD like apoptosis regulator  / complex / reaction
 ENSG00000168404 MLKL / Q8NB16 / mixed lineage kinase domain like pseudokinase  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / - / reaction / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000143258 USP21 / Q9UK80 / ubiquitin specific peptidase 21  / complex
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000083799 CYLD / Q9NQC7 / CYLD lysine 63 deubiquitinase  / complex
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / reaction / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction / complex
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / reaction / complex
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / complex / reaction






 

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