ENSG00000168404


Homo sapiens

Features
Gene ID: ENSG00000168404
  
Biological name :MLKL
  
Synonyms : mixed lineage kinase domain like pseudokinase / MLKL / Q8NB16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q23.1
Gene start: 74671855
Gene end: 74700960
  
Corresponding Affymetrix probe sets: 238025_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461666
Ensembl peptide - ENSP00000459935
Ensembl peptide - ENSP00000461110
Ensembl peptide - ENSP00000303118
Ensembl peptide - ENSP00000308351
Ensembl peptide - ENSP00000459920
NCBI entrez gene - 197259     See in Manteia.
OMIM - 615153
RefSeq - XM_005255834
RefSeq - NM_001142497
RefSeq - NM_152649
RefSeq Peptide - NP_001135969
RefSeq Peptide - NP_689862
swissprot - I3L2T9
swissprot - I3L4Z5
swissprot - I3L4A6
swissprot - I3L2U3
swissprot - Q8NB16
Ensembl - ENSG00000168404
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MLKLENSGALG00000002766Gallus gallus
 MlklENSMUSG00000012519Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0070207 protein homotrimerization IDA
 biological_processGO:0070266 necroptotic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
TRP channels
RIPK1-mediated regulated necrosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000168404 MLKL / Q8NB16 / mixed lineage kinase domain like pseudokinase  / reaction / - / complex






 

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