8737


Homo sapiens (NCBI)

Features
Gene ID: 8737
  
Biological name :
  
Synonyms : receptor interacting serine/threonine kinase 1 / RIPK1 / RIP|RIP-1|RIP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 209941_at (Human Genome U133 Plus 2.0 Array)   226551_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 1034652028
RefSeq - 1034652030
RefSeq - 1034652032
RefSeq - 1238280176
RefSeq - 1238280194
RefSeq - 1238280234
RefSeq - 1238280241
RefSeq - 1238280260
RefSeq - 57242761
RefSeq - 767940908
RefSeq - 951231042
RefSeq - NC_000006.12
RefSeq - NP_001303990.1
RefSeq - NP_001341859.1
RefSeq - NP_001341860.1
RefSeq - NP_001341861.1
RefSeq - NP_001341862.1
RefSeq - NP_001341863.1
RefSeq - NP_003795.2
RefSeq - XP_006715300.2
RefSeq - XP_016866892.1
RefSeq - XP_016866893.1
RefSeq - XP_016866894.1
RefSeq - NM_001317061.2
RefSeq - NM_001354930.1
RefSeq - NM_001354931.1
RefSeq - NM_001354932.1
RefSeq - NM_001354933.1
RefSeq - NM_001354934.1
RefSeq - NM_003804.5
RefSeq - XM_017011403.1
RefSeq - XM_017011404.2
RefSeq - XM_017011405.1
RefSeq - XM_006715237.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000137275 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0010940 positive regulation of necrotic cell death IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0034138 toll-like receptor 3 signaling pathway TAS
 biological_processGO:0034612 response to tumor necrosis factor IMP
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0036289 peptidyl-serine autophosphorylation IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043068 positive regulation of programmed cell death IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0044257 cellular protein catabolic process IDA
 biological_processGO:0045651 positive regulation of macrophage differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051291 protein heterooligomerization IMP
 biological_processGO:0060545 positive regulation of necroptotic process IMP
 biological_processGO:0070231 T cell apoptotic process ISS
 biological_processGO:0070266 necroptotic process TAS
 biological_processGO:0070926 regulation of ATP:ADP antiporter activity IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071550 death-inducing signaling complex assembly TAS
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IMP
 biological_processGO:0097343 ripoptosome assembly IMP
 biological_processGO:0097527 necroptotic signaling pathway ISS
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
 biological_processGO:1905206 positive regulation of hydrogen peroxide-induced cell death IMP
 biological_processGO:1990000 amyloid fibril formation IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process TAS
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0031264 death-inducing signaling complex IDA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0097342 ripoptosome IDA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004706 JUN kinase kinase kinase activity IBA
 molecular_functionGO:0005123 death receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0070513 death domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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