ENSG00000110514


Homo sapiens

Features
Gene ID: ENSG00000110514
  
Biological name :MADD
  
Synonyms : MADD / MAP kinase activating death domain / Q8WXG6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 47269161
Gene end: 47330031
  
Corresponding Affymetrix probe sets: 210252_s_at (Human Genome U133 Plus 2.0 Array)   38398_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384483
Ensembl peptide - ENSP00000384435
Ensembl peptide - ENSP00000385585
Ensembl peptide - ENSP00000489300
Ensembl peptide - ENSP00000413116
Ensembl peptide - ENSP00000402364
Ensembl peptide - ENSP00000398167
Ensembl peptide - ENSP00000388255
Ensembl peptide - ENSP00000304505
Ensembl peptide - ENSP00000310933
Ensembl peptide - ENSP00000343902
Ensembl peptide - ENSP00000378745
Ensembl peptide - ENSP00000378753
Ensembl peptide - ENSP00000384204
Ensembl peptide - ENSP00000384287
NCBI entrez gene - 8567     See in Manteia.
OMIM - 603584
RefSeq - XM_017018510
RefSeq - XM_017018492
RefSeq - XM_017018493
RefSeq - XM_017018494
RefSeq - XM_017018495
RefSeq - XM_017018496
RefSeq - XM_017018497
RefSeq - XM_017018498
RefSeq - XM_017018499
RefSeq - XM_017018500
RefSeq - XM_017018501
RefSeq - XM_017018502
RefSeq - XM_017018503
RefSeq - XM_017018504
RefSeq - XM_017018505
RefSeq - XM_017018506
RefSeq - XM_017018507
RefSeq - XM_017018508
RefSeq - XM_017018509
RefSeq - NM_001135943
RefSeq - NM_001135944
RefSeq - NM_003682
RefSeq - NM_130470
RefSeq - NM_130471
RefSeq - NM_130472
RefSeq - NM_130473
RefSeq - NM_130474
RefSeq - NM_130475
RefSeq - NM_130476
RefSeq - XM_005253189
RefSeq - XM_005253196
RefSeq - XM_005253199
RefSeq - XM_005253200
RefSeq - XM_005253201
RefSeq - XM_005253203
RefSeq - XM_005253204
RefSeq - XM_005253205
RefSeq - XM_017018478
RefSeq - XM_017018479
RefSeq - XM_017018480
RefSeq - XM_017018481
RefSeq - XM_017018482
RefSeq - XM_017018483
RefSeq - XM_017018484
RefSeq - XM_017018485
RefSeq - XM_017018486
RefSeq - XM_017018487
RefSeq - XM_017018488
RefSeq - XM_017018489
RefSeq - XM_017018490
RefSeq - XM_017018491
RefSeq Peptide - NP_001129416
RefSeq Peptide - NP_569826
RefSeq Peptide - NP_569827
RefSeq Peptide - NP_569828
RefSeq Peptide - NP_569829
RefSeq Peptide - NP_569830
RefSeq Peptide - NP_569831
RefSeq Peptide - NP_569832
RefSeq Peptide - NP_001129415
RefSeq Peptide - NP_003673
swissprot - C9JM97
swissprot - C9JLZ9
swissprot - C9J6B0
swissprot - A0A0U1RR25
swissprot - F8W8U2
swissprot - A0A0A0MRB5
swissprot - C9K0L0
swissprot - Q8WXG6
Ensembl - ENSG00000110514
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maddENSDARG00000003495Danio rerio
 MADDENSGALG00000008181Gallus gallus
 MaddENSMUSG00000040687Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448518
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714518
O75064 / DENND4B / DENN domain containing 4BENSG0000019883715
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401410
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045610
A2RUS2 / DENND3 / DENN domain containing 3ENSG000001053398
Q8TEH3 / DENND1A / DENN domain containing 1AENSG000001195228
Q8IV53 / DENND1C / DENN domain containing 1CENSG000002057447
Q6P3S1 / DENND1B / DENN domain containing 1BENSG000002130477
ST5 / P78524 / suppression of tumorigenicity 5ENSG000001664446
Q9ULE3 / DENND2A / DENN domain containing 2AENSG000001469666
Q68D51 / DENND2C / DENN domain containing 2CENSG000001759846
Q9H6A0 / DENND2D / DENN domain containing 2DENSG000001627775


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR011993  PH-like domain superfamily
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0032483 regulation of Rab protein signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0097194 execution phase of apoptosis IMP
 biological_processGO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
 biological_processGO:2001236 regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005123 death receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0030295 protein kinase activator activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000105649 RAB3A / P20336 / RAB3A, member RAS oncogene family  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000069974 P51159 / RAB27A / RAB27A, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / reaction / complex






 

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