ENSG00000137145


Homo sapiens

Features
Gene ID: ENSG00000137145
  
Biological name :DENND4C
  
Synonyms : DENND4C / DENN domain containing 4C / Q5VZ89
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p22.1
Gene start: 19230435
Gene end: 19373545
  
Corresponding Affymetrix probe sets: 205684_s_at (Human Genome U133 Plus 2.0 Array)   226867_at (Human Genome U133 Plus 2.0 Array)   234968_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369789
Ensembl peptide - ENSP00000473469
Ensembl peptide - ENSP00000354301
Ensembl peptide - ENSP00000473565
Ensembl peptide - ENSP00000369792
Ensembl peptide - ENSP00000473273
NCBI entrez gene - 55667     See in Manteia.
RefSeq - XM_017014920
RefSeq - NM_017925
RefSeq - XM_006716804
RefSeq - XM_006716805
RefSeq - XM_006716807
RefSeq - XM_011517959
RefSeq - XM_017014917
RefSeq - XM_017014918
RefSeq - XM_017014919
RefSeq Peptide - NP_001317569
RefSeq Peptide - NP_060395
swissprot - Q5VZ89
swissprot - R4GMN2
swissprot - X6R5W5
swissprot - X6RAE7
swissprot - A0A0A0MRX3
Ensembl - ENSG00000137145
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd4cENSDARG00000102766Danio rerio
 DENND4CENSGALG00000015083Gallus gallus
 A6H8H2ENSMUSG00000038024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448549
O75064 / DENND4B / DENN domain containing 4BENSG0000019883734
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051415
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401412
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045611
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952210
A2RUS2 / DENND3 / DENN domain containing 3ENSG000001053399
Q8IV53 / DENND1C / DENN domain containing 1CENSG000002057449
Q6P3S1 / DENND1B / DENN domain containing 1BENSG000002130478
ST5 / P78524 / suppression of tumorigenicity 5ENSG000001664448
Q9ULE3 / DENND2A / DENN domain containing 2AENSG000001469667
Q68D51 / DENND2C / DENN domain containing 2CENSG000001759847
Q9H6A0 / DENND2D / DENN domain containing 2DENSG000001627776


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR023341  MABP domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0072659 protein localization to plasma membrane ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030904 retromer complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032593 insulin-responsive compartment ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000084733 RAB10 / P61026 / RAB10, member RAS oncogene family  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr