ENSG00000170456


Homo sapiens

Features
Gene ID: ENSG00000170456
  
Biological name :DENND5B
  
Synonyms : DENND5B / DENN domain containing 5B / Q6ZUT9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p11.21
Gene start: 31382223
Gene end: 31591097
  
Corresponding Affymetrix probe sets: 215058_at (Human Genome U133 Plus 2.0 Array)   228551_at (Human Genome U133 Plus 2.0 Array)   236415_at (Human Genome U133 Plus 2.0 Array)   238917_s_at (Human Genome U133 Plus 2.0 Array)   243613_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373734
Ensembl peptide - ENSP00000444889
Ensembl peptide - ENSP00000445113
Ensembl peptide - ENSP00000346238
Ensembl peptide - ENSP00000442938
NCBI entrez gene - 160518     See in Manteia.
OMIM - 617279
RefSeq - XM_017018899
RefSeq - XM_005253330
RefSeq - XM_006719040
RefSeq - XM_011520590
RefSeq - XM_017018896
RefSeq - XM_017018897
RefSeq - XM_017018898
RefSeq - NM_001308339
RefSeq - NM_144973
RefSeq - XM_005253326
RefSeq - XM_005253327
RefSeq Peptide - NP_001295268
RefSeq Peptide - NP_659410
swissprot - G3V1S3
swissprot - H0YGE5
swissprot - Q6ZUT9
swissprot - F5H4A0
Ensembl - ENSG00000170456
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NXD8ENSDARG00000003789Danio rerio
 ENSGALG00000045990Gallus gallus
 ENSGALG00000012944Gallus gallus
 A2RSQ0ENSMUSG00000030313Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401469
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448517
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714517
O75064 / DENND4B / DENN domain containing 4BENSG0000019883715
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051412
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533912
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952210
Q6P3S1 / DENND1B / DENN domain containing 1BENSG0000021304710
ST5 / P78524 / suppression of tumorigenicity 5ENSG000001664449
Q9ULE3 / DENND2A / DENN domain containing 2AENSG000001469669
Q68D51 / DENND2C / DENN domain containing 2CENSG000001759849
Q8IV53 / DENND1C / DENN domain containing 1CENSG000002057449
Q9H6A0 / DENND2D / DENN domain containing 2DENSG000001627777


Protein motifs (from Interpro)
Interpro ID Name
 IPR001024  PLAT/LH2 domain
 IPR001194  cDENN domain
 IPR004012  RUN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR036392  PLAT/LH2 domain superfamily
 IPR037213  RUN domain superfamily
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000179331 Q14964 / RAB39A / RAB39A, member RAS oncogene family  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction






 

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