ENSG00000213047


Homo sapiens

Features
Gene ID: ENSG00000213047
  
Biological name :DENND1B
  
Synonyms : DENND1B / DENN domain containing 1B / Q6P3S1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q31.3
Gene start: 197504748
Gene end: 197775696
  
Corresponding Affymetrix probe sets: 1552835_at (Human Genome U133 Plus 2.0 Array)   1557309_at (Human Genome U133 Plus 2.0 Array)   1564164_at (Human Genome U133 Plus 2.0 Array)   219696_at (Human Genome U133 Plus 2.0 Array)   228032_s_at (Human Genome U133 Plus 2.0 Array)   238787_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479816
Ensembl peptide - ENSP00000294737
Ensembl peptide - ENSP00000356366
Ensembl peptide - ENSP00000410025
Ensembl peptide - ENSP00000235453
NCBI entrez gene - 163486     See in Manteia.
OMIM - 613292
RefSeq - XM_017000472
RefSeq - XM_011509247
RefSeq - XM_011509248
RefSeq - XM_011509249
RefSeq - XM_011509251
RefSeq - XM_017000470
RefSeq - XM_017000471
RefSeq - NM_001195215
RefSeq - NM_001300858
RefSeq - NM_144977
RefSeq - XM_005244931
RefSeq - XM_006711192
RefSeq - XM_006711193
RefSeq - XM_011509246
RefSeq Peptide - NP_659414
RefSeq Peptide - NP_001182144
RefSeq Peptide - NP_001287787
swissprot - B7ZBL5
swissprot - Q6P3S1
swissprot - B3KR95
Ensembl - ENSG00000213047
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd1bENSDARG00000101868Danio rerio
 DENND1BENSGALG00000002246Gallus gallus
 Q3U1T9ENSMUSG00000056268Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEH3 / DENND1A / DENN domain containing 1AENSG0000011952248
Q8IV53 / DENND1C / DENN domain containing 1CENSG0000020574438
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714520
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448520
O75064 / DENND4B / DENN domain containing 4BENSG0000019883718
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045617
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401417
Q9ULE3 / DENND2A / DENN domain containing 2AENSG0000014696616
ST5 / P78524 / suppression of tumorigenicity 5ENSG0000016644416
Q68D51 / DENND2C / DENN domain containing 2CENSG0000017598416
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051415
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533914
Q9H6A0 / DENND2D / DENN domain containing 2DENSG0000016277714


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032456 endocytic recycling ISS
 biological_processGO:0035745 T-helper 2 cell cytokine production IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050776 regulation of immune response ISS
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017137 Rab GTPase binding IEA


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000111737 RAB35 / Q15286 / RAB35, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction






 

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