ENSG00000119522


Homo sapiens

Features
Gene ID: ENSG00000119522
  
Biological name :DENND1A
  
Synonyms : DENND1A / DENN domain containing 1A / Q8TEH3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.3
Gene start: 123379654
Gene end: 123930152
  
Corresponding Affymetrix probe sets: 219763_at (Human Genome U133 Plus 2.0 Array)   226849_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377763
Ensembl peptide - ENSP00000362720
Ensembl peptide - ENSP00000362722
Ensembl peptide - ENSP00000362727
NCBI entrez gene - 57706     See in Manteia.
OMIM - 613633
RefSeq - XM_017014952
RefSeq - NM_001352968
RefSeq - NM_020946
RefSeq - NM_024820
RefSeq - XM_017014947
RefSeq - XM_017014948
RefSeq - XM_017014949
RefSeq - XM_017014950
RefSeq - XM_017014951
RefSeq - XM_005252109
RefSeq - XM_005252111
RefSeq - XM_005252113
RefSeq - XM_006717195
RefSeq - XM_011518882
RefSeq - XM_011518883
RefSeq - XM_011518884
RefSeq - XM_011518885
RefSeq - XM_011518886
RefSeq - XM_011518887
RefSeq Peptide - NP_001339897
RefSeq Peptide - NP_065997
RefSeq Peptide - NP_079096
swissprot - Q8TEH3
swissprot - A0A0A0MS48
Ensembl - ENSG00000119522
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dennd1aENSDARG00000014592Danio rerio
 DENND1AENSGALG00000001157Gallus gallus
 Q8K382ENSMUSG00000035392Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6P3S1 / DENND1B / DENN domain containing 1BENSG0000021304737
Q8IV53 / DENND1C / DENN domain containing 1CENSG0000020574431
Q5VZ89 / DENND4C / DENN domain containing 4CENSG0000013714519
Q7Z401 / DENND4A / DENN domain containing 4AENSG0000017448519
O75064 / DENND4B / DENN domain containing 4BENSG0000019883717
Q6IQ26 / DENND5A / DENN domain containing 5AENSG0000018401414
Q6ZUT9 / DENND5B / DENN domain containing 5BENSG0000017045613
Q9ULE3 / DENND2A / DENN domain containing 2AENSG0000014696613
ST5 / P78524 / suppression of tumorigenicity 5ENSG0000016644413
MADD / Q8WXG6 / MAP kinase activating death domainENSG0000011051413
A2RUS2 / DENND3 / DENN domain containing 3ENSG0000010533913
Q68D51 / DENND2C / DENN domain containing 2CENSG0000017598412
Q9H6A0 / DENND2D / DENN domain containing 2DENSG0000016277710


Protein motifs (from Interpro)
Interpro ID Name
 IPR001194  cDENN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032456 endocytic recycling ISS
 biological_processGO:0032483 regulation of Rab protein signal transduction IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding ISS
 molecular_functionGO:1901981 phosphatidylinositol phosphate binding ISS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / reaction
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / reaction
 ENSG00000108953 YWHAE / P62258 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon  / reaction / complex
 ENSG00000111737 RAB35 / Q15286 / RAB35, member RAS oncogene family  / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / reaction






 

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