ENSMUSG00000030313


Mus musculus

Features
Gene ID: ENSMUSG00000030313
  
Biological name :Dennd5b
  
Synonyms : A2RSQ0 / Dennd5b / DENN domain-containing protein 5B
  
Possible biological names infered from orthology : DENN domain containing 5B / Q6ZUT9
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G3
Gene start: 148988071
Gene end: 149101680
  
Corresponding Affymetrix probe sets: 10549504 (MoGene1.0st)   10549506 (MoGene1.0st)   1443665_at (Mouse Genome 430 2.0 Array)   1455340_at (Mouse Genome 430 2.0 Array)   1456422_at (Mouse Genome 430 2.0 Array)   1458146_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107182
Ensembl peptide - ENSMUSP00000127731
Ensembl peptide - ENSMUSP00000123568
NCBI entrez gene - 320560     See in Manteia.
MGI - MGI:2444273
RefSeq - XM_006507062
RefSeq - XM_017321643
RefSeq - XM_011241617
RefSeq - NM_177192
RefSeq - XM_006507063
RefSeq Peptide - NP_796166
swissprot - E9Q0R9
swissprot - A2RSQ0
swissprot - B8JKU3
Ensembl - ENSMUSG00000030313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NXD8ENSDARG00000003789Danio rerio
 ENSGALG00000045990Gallus gallus
 ENSGALG00000012944Gallus gallus
 Q6ZUT9ENSG00000170456Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*ENSMUSG0000003590171
A6H8H2 / Dennd4c / DENN domain-containing protein 4C / Q5VZ89* / DENN domain containing 4C*ENSMUSG0000003802418
Dennd4a / DENN domain containing 4A / Q7Z401*ENSMUSG0000005364117
Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*ENSMUSG0000004240416
Madd / MAP-kinase activating death domain / Q8WXG6*ENSMUSG0000004068713
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*ENSMUSG0000003666112
Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*ENSMUSG0000003539210
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*ENSMUSG0000005626810
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*ENSMUSG000000026689
Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*ENSMUSG000000384569
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*ENSMUSG000000310249
Dennd2c / DENN domain containing 2C / Q68D51*ENSMUSG000000073798
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*ENSMUSG000000279017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001024  PLAT/LH2 domain
 IPR001194  cDENN domain
 IPR004012  RUN domain
 IPR005112  dDENN domain
 IPR005113  uDENN domain
 IPR036392  PLAT/LH2 domain superfamily
 IPR037213  RUN domain superfamily
 IPR037516  Tripartite DENN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017112 Rab guanyl-nucleotide exchange factor activity ISS


Pathways (from Reactome)
Pathway description
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000055069 Rab39 / Q8BHD0 / RAB39, member RAS oncogene family / Q14964* / RAB39A* / RAB39A, member RAS oncogene family*  / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / reaction






 

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