Manteia

ENSMUSG00000038024

Mus musculus

Features

Gene ID:	ENSMUSG00000038024

Biological name :	Dennd4c

Synonyms :	A6H8H2 / Dennd4c / DENN domain-containing protein 4C

Possible biological names infered from orthology :	DENN domain containing 4C / Q5VZ89

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	C4
Gene start:	86748555
Gene end:	86850603

Corresponding Affymetrix probe sets:	10505749 (MoGene1.0st) 1434846_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000080685 Ensembl peptide - ENSMUSP00000123367 Ensembl peptide - ENSMUSP00000039860 NCBI entrez gene - 329877 See in Manteia. MGI - MGI:1914769 RefSeq - XM_006538022 RefSeq - XM_006538024 RefSeq - NM_184088 RefSeq - XM_006538023 RefSeq Peptide - NP_908976 swissprot - E9Q449 swissprot - A6H8H2 Ensembl - ENSMUSG00000038024

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dennd4a / DENN domain containing 4A / Q7Z401*	ENSMUSG00000053641	49
Q3U1Y4 / Dennd4b / Mus musculus DENN/MADD domain containing 4B (Dennd4b), transcript variant 2, mRNA. / O75064* / DENN domain containing 4B*	ENSMUSG00000042404	36
Madd / MAP-kinase activating death domain / Q8WXG6*	ENSMUSG00000040687	15
A2RSQ0 / Dennd5b / DENN domain-containing protein 5B / Q6ZUT9* / DENN domain containing 5B*	ENSMUSG00000030313	12
Q6PAL8 / Dennd5a / DENN domain-containing protein 5A / Q6IQ26* / DENN domain containing 5A*	ENSMUSG00000035901	12
Q8K382 / Dennd1a / DENN domain-containing protein 1A / Q8TEH3* / DENN domain containing 1A*	ENSMUSG00000035392	10
A2RT67 / Dennd3 / DENN domain-containing protein 3 / A2RUS2* / DENN domain containing 3*	ENSMUSG00000036661	10
Q8CFK6 / Dennd1c / DENN domain-containing protein 1C / Q8IV53* / DENN domain containing 1C*	ENSMUSG00000002668	8
Q3U1T9 / Dennd1b / DENN domain-containing protein 1B / Q6P3S1* / DENN domain containing 1B*	ENSMUSG00000056268	8
Dennd2c / DENN domain containing 2C / Q68D51*	ENSMUSG00000007379	7
Q8C4S8 / Dennd2a / DENN domain-containing protein 2A / Q9ULE3* / DENN domain containing 2A*	ENSMUSG00000038456	7
St5 / Q924W7 / Suppression of tumorigenicity 5 protein / P78524* / suppression of tumorigenicity 5*	ENSMUSG00000031024	7
Q91VV4 / Dennd2d / DENN domain-containing protein 2D / Q9H6A0* / DENN domain containing 2D*	ENSMUSG00000027901	6

Protein motifs (from Interpro)

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0032869	cellular response to insulin stimulus	IMP
biological_process	GO:0065009	regulation of molecular function	IEA
biological_process	GO:0072659	protein localization to plasma membrane	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030659	cytoplasmic vesicle membrane	IEA
cellular_component	GO:0030904	retromer complex	IDA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0032593	insulin-responsive compartment	IDA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	ISO
molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0017112	Rab guanyl-nucleotide exchange factor activity	IEA

Pathways (from Reactome)

Pathway description

RAB GEFs exchange GTP for GDP on RABs

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics
MP:0010851	decreased effector memory CD8-positive, alpha-beta T cell number	"reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺ Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ucd
MP:0013294	prenatal lethality prior to heart atrial septation	"death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]	Show Allelic Composition: Dbn1^{tm1b(KOMP)Wtsi}/Dbn1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000025531	Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*	/ reaction
ENSMUSG00000020671	Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*	/ reaction
ENSMUSG00000078185	Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*	/ reaction
ENSMUSG00000015291	Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*	/ reaction
ENSMUSG00000021218	Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr