ENSG00000105649


Homo sapiens

Features
Gene ID: ENSG00000105649
  
Biological name :RAB3A
  
Synonyms : P20336 / RAB3A / RAB3A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.11
Gene start: 18196784
Gene end: 18204074
  
Corresponding Affymetrix probe sets: 204974_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474603
Ensembl peptide - ENSP00000222256
Ensembl peptide - ENSP00000472335
NCBI entrez gene - 5864     See in Manteia.
OMIM - 179490
RefSeq - XM_011528164
RefSeq - NM_002866
RefSeq Peptide - NP_002857
swissprot - A0A024R7I7
swissprot - P20336
swissprot - S4R3Q3
swissprot - M0R257
Ensembl - ENSG00000105649
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab3aaENSDARG00000056347Danio rerio
 rab3abENSDARG00000043835Danio rerio
 RAB3AENSGALG00000030068Gallus gallus
 Rab3aENSMUSG00000031840Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB3C / Q96E17 / RAB3C, member RAS oncogene familyENSG0000015293284
RAB3B / P20337 / RAB3B, member RAS oncogene familyENSG0000016921378
RAB3D / O95716 / RAB3D, member RAS oncogene familyENSG0000010551477
RAB8A / P61006 / RAB8A, member RAS oncogene familyENSG0000016746147
RAB8B / Q92930 / RAB8B, member RAS oncogene familyENSG0000016612844
RAB10 / P61026 / RAB10, member RAS oncogene familyENSG0000008473342
RAB12 / Q6IQ22 / RAB12, member RAS oncogene familyENSG0000020641842
RAB13 / P51153 / RAB13, member RAS oncogene familyENSG0000014354541
P51159 / RAB27A / RAB27A, member RAS oncogene familyENSG0000006997440
O00194 / RAB27B / RAB27B, member RAS oncogene familyENSG0000004135339
RAB44 / RAB44, member RAS oncogene familyENSG0000025558738
RAB15 / P59190 / RAB15, member RAS oncogene familyENSG0000013999837
RASEF / Q8IZ41 / RAS and EF-hand domain containingENSG0000016510533


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003016 respiratory system process IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007269 neurotransmitter secretion TAS
 biological_processGO:0007274 neuromuscular synaptic transmission IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016079 synaptic vesicle exocytosis ISS
 biological_processGO:0016188 synaptic vesicle maturation IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane ISS
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0036465 synaptic vesicle recycling ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045054 constitutive secretory pathway TAS
 biological_processGO:0045921 positive regulation of exocytosis TAS
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity ISS
 biological_processGO:0048790 maintenance of presynaptic active zone structure IEA
 biological_processGO:0050975 sensory perception of touch IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0061670 evoked neurotransmitter secretion IEA
 biological_processGO:1903307 positive regulation of regulated secretory pathway IMP
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0043195 terminal bouton ISS
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane TAS
 cellular_componentGO:0060203 clathrin-sculpted glutamate transport vesicle membrane TAS
 cellular_componentGO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
 cellular_componentGO:0070083 clathrin-sculpted monoamine transport vesicle membrane TAS
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 cellular_componentGO:1903561 extracellular vesicle HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0031489 myosin V binding IPI
 molecular_functionGO:0051021 GDP-dissociation inhibitor binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187714 Q16572 / SLC18A3 / solute carrier family 18 member A3  / complex / reaction
 ENSG00000067715 SYT1 / P21579 / synaptotagmin 1  / complex
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000104888 Q9P2U7 / SLC17A7 / solute carrier family 17 member 7  / complex
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000110514 MADD / Q8WXG6 / MAP kinase activating death domain  / reaction
 ENSG00000167994 Q8TBN0 / RAB3IL1 / RAB3A interacting protein like 1  / reaction
 ENSG00000220205 VAMP2 / P63027 / vesicle associated membrane protein 2  / complex






 

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