ENSMUSG00000031840


Mus musculus

Features
Gene ID: ENSMUSG00000031840
  
Biological name :Rab3a
  
Synonyms : P63011 / Rab3a / RAB3A, member RAS oncogene family
  
Possible biological names infered from orthology : P20336
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70754679
Gene end: 70758677
  
Corresponding Affymetrix probe sets: 10572485 (MoGene1.0st)   1422589_at (Mouse Genome 430 2.0 Array)   1459980_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105717
Ensembl peptide - ENSMUSP00000105720
Ensembl peptide - ENSMUSP00000123384
Ensembl peptide - ENSMUSP00000034301
Ensembl peptide - ENSMUSP00000105719
NCBI entrez gene - 19339     See in Manteia.
MGI - MGI:97843
RefSeq - XM_006509603
RefSeq - NM_001166399
RefSeq - NM_001328047
RefSeq - NM_009001
RefSeq Peptide - NP_001159871
RefSeq Peptide - NP_001314976
RefSeq Peptide - NP_033027
swissprot - P63011
swissprot - Q0PD63
swissprot - D3YZP5
Ensembl - ENSMUSG00000031840
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab3aaENSDARG00000056347Danio rerio
 rab3abENSDARG00000043835Danio rerio
 RAB3AENSGALG00000030068Gallus gallus
 RAB3AENSG00000105649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab3c / P62823 / RAB3C, member RAS oncogene family / Q96E17*ENSMUSG0000002170083
Rab3b / Q9CZT8 / RAB3B, member RAS oncogene family / P20337*ENSMUSG0000000341178
Rab3d / P35276 / RAB3D, member RAS oncogene family / O95716*ENSMUSG0000001906675
Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*ENSMUSG0000000303746
Rab8b / P61028 / RAB8B, member RAS oncogene family / Q92930*ENSMUSG0000003694344
Rab10 / P61027 / RAB10, member RAS oncogene family / P61026*ENSMUSG0000002067142
Rab13 / Q9DD03 / Ras-related protein Rab-13 / P51153* / RAB13, member RAS oncogene family*ENSMUSG0000002793542
Rab12 / P35283 / Ras-related protein Rab-12 / Q6IQ22* / RAB12, member RAS oncogene family*ENSMUSG0000002346042
Q9ERI2 / Rab27a / RAB27A, member RAS oncogene family / P51159*ENSMUSG0000003220240
Q99P58 / Rab27b / RAB27B, member RAS oncogene family / O00194*ENSMUSG0000002451138
Rab15 / RAB15, member RAS oncogene family / P59190*ENSMUSG0000002106237
Rab44 / Q8CB87 / Ras-related protein Rab-44 / RAB44, member RAS oncogene family*ENSMUSG0000006414734
Rasef / Q5RI75 / Ras and EF-hand domain-containing protein homolog / Q8IZ41* / RAS and EF-hand domain containing*ENSMUSG0000004300334


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0016188 synaptic vesicle maturation IMP
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0030324 lung development IMP
 biological_processGO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane IMP
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0036465 synaptic vesicle recycling IEA
 biological_processGO:0048172 regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0048489 synaptic vesicle transport TAS
 biological_processGO:0048790 maintenance of presynaptic active zone structure IMP
 biological_processGO:0050975 sensory perception of touch IMP
 biological_processGO:0051602 response to electrical stimulus IMP
 biological_processGO:0061670 evoked neurotransmitter secretion IMP
 biological_processGO:1900271 regulation of long-term synaptic potentiation TAS
 biological_processGO:1903307 positive regulation of regulated secretory pathway IEA
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043195 terminal bouton IDA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0098993 anchored component of synaptic vesicle membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001671 ATPase activator activity IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IPI
 molecular_functionGO:0031489 myosin V binding IEA
 molecular_functionGO:0051021 GDP-dissociation inhibitor binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129P2/OlaHsd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud
Genetic Background: involves: 129

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: RelbTg(H2-K1/GH1)106Bri/RelbTg(H2-K1/GH1)106Bri
Genetic Background: C57BL/6-RelbTg(H2-K1/GH1)106Bri

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab3atm1Sud/Rab3a+,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3b+,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3c+,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3btm1Sud/Rab3btm1Sud,Rab3ctm1Sud/Rab3ctm1Sud
Genetic Background: involves: 129 * 129P2/OlaHsd

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud,Rab3ctm1Sud/Rab3ctm1Sud,Rab3dtm1Rja/Rab3dtm1Rja
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Cln8mnd/Cln8mnd
Genetic Background: involves: AKR/J * B6.KB2

Allelic Composition: Rab3aEbd/Rab3a+
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Rab3aEbd/Rab3aEbd
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Rab3atm1Sud/Rab3a+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Rab3atm1Sud/Rab3atm1Sud
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000070570 Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1 / Q9P2U7* / solute carrier family 17 member 7*  / complex
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000035864 Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*  / complex
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex
 ENSMUSG00000024663 Q8VDV3 / Rab3il1 / Mus musculus RAB3A interacting protein (rabin3)-like 1 (Rab3il1), transcript variant 2, mRNA. / Q8TBN0* / RAB3A interacting protein like 1*  / reaction
 ENSMUSG00000100241 Slc18a3 / solute carrier family 18 member A3 / Q16572*  / reaction / complex






 

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