ENSMUSG00000100241


Mus musculus

Features
Gene ID: ENSMUSG00000100241
  
Biological name :Slc18a3
  
Synonyms : Slc18a3 / solute carrier family 18 member A3
  
Possible biological names infered from orthology : Q16572
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 32462438
Gene end: 32464850
  
Corresponding Affymetrix probe sets: 10418835 (MoGene1.0st)   1422203_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139829
NCBI entrez gene - 20508     See in Manteia.
MGI - MGI:1101061
RefSeq - NM_021712
RefSeq Peptide - NP_068358
swissprot - Q3TYJ1
Ensembl - ENSMUSG00000100241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01112647.1ENSDARG00000107527Danio rerio
 Q08C75ENSDARG00000006356Danio rerio
 SLC18A3ENSGALG00000041103Gallus gallus
 Q16572ENSG00000187714Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R090 / Slc18a1 / Chromaffin granule amine transporter / P54219* / solute carrier family 18 member A1*ENSMUSG0000003633036
Q8BRU6 / Slc18a2 / Synaptic vesicular amine transporter / Q05940* / solute carrier family 18 member A2*ENSMUSG0000002509435
D3Z5L6 / Slc18b1 / Mus musculus solute carrier family 18, subfamily B, member 1 (Slc18b1), transcript variant 2, mRNA. / Q6NT16* / solute carrier family 18 member B1*ENSMUSG0000003745518


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Acetylcholine Neurotransmitter Release Cycle
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Slc18a3tm1Mca/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Slc18a3tm1Mca/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Slc18a3tm1Mca/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002204 abnormal neurotransmitter physiology "aberrant function or production of endogenous signaling molecules secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Slc18a3tm1Mca/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chat/Slc18a3tm1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004836 abnormal synaptic acetylcholine release "aberrant secretion across synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Slc18a3tm1Mca/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Chat/Slc18a3tm1.1Vpra
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex / reaction
 ENSMUSG00000035864 Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*  / complex / reaction
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / reaction / complex
 ENSMUSG00000100241 Slc18a3 / solute carrier family 18 member A3 / Q16572*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr