ENSMUSG00000036330


Mus musculus

Features
Gene ID: ENSMUSG00000036330
  
Biological name :Slc18a1
  
Synonyms : Chromaffin granule amine transporter / Q8R090 / Slc18a1
  
Possible biological names infered from orthology : P54219 / solute carrier family 18 member A1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 69037711
Gene end: 69089235
  
Corresponding Affymetrix probe sets: 10579023 (MoGene1.0st)   1426595_at (Mouse Genome 430 2.0 Array)   1446248_at (Mouse Genome 430 2.0 Array)   1458777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046924
Ensembl peptide - ENSMUSP00000148432
NCBI entrez gene - 110877     See in Manteia.
MGI - MGI:106684
RefSeq - XM_017312522
RefSeq - NM_153054
RefSeq - XM_006509534
RefSeq - XM_011242262
RefSeq Peptide - NP_694694
swissprot - Q8R090
swissprot - A0A1D5RLM7
swissprot - Q32XG7
Ensembl - ENSMUSG00000036330
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX088696.1ENSDARG00000078157Danio rerio
 SLC18A1ENSGALG00000001693Gallus gallus
 P54219ENSG00000036565Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BRU6 / Slc18a2 / Synaptic vesicular amine transporter / Q05940* / solute carrier family 18 member A2*ENSMUSG0000002509461
Slc18a3 / solute carrier family 18 member A3 / Q16572*ENSMUSG0000010024137
D3Z5L6 / Slc18b1 / Mus musculus solute carrier family 18, subfamily B, member 1 (Slc18b1), transcript variant 2, mRNA. / Q6NT16* / solute carrier family 18 member B1*ENSMUSG0000003745519


Protein motifs (from Interpro)
Interpro ID Name
 IPR004734  Multidrug resistance protein
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006837 serotonin transport IEA
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0015842 aminergic neurotransmitter loading into synaptic vesicle IBA
 biological_processGO:0015893 drug transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0015222 serotonin transmembrane transporter activity IBA
 molecular_functionGO:0015238 drug transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Na+/Cl- dependent neurotransmitter transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Smarce1tm1Tich/Smarce1tm1Tich
Genetic Background: involves: 129

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Smarce1tm1Tich/Smarce1tm1Tich
Genetic Background: involves: 129

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smarce1tm1Tich/Smarce1tm1Tich
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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