ENSMUSG00000035864


Mus musculus

Features
Gene ID: ENSMUSG00000035864
  
Biological name :Syt1
  
Synonyms : P46096 / synaptotagmin I / Syt1
  
Possible biological names infered from orthology : P21579 / synaptotagmin 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 108497650
Gene end: 109010982
  
Corresponding Affymetrix probe sets: 10372324 (MoGene1.0st)   1421990_at (Mouse Genome 430 2.0 Array)   1431191_a_at (Mouse Genome 430 2.0 Array)   1433884_at (Mouse Genome 430 2.0 Array)   1438282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063293
Ensembl peptide - ENSMUSP00000100912
NCBI entrez gene - 20979     See in Manteia.
MGI - MGI:99667
RefSeq - NM_001358502
RefSeq - NM_001358503
RefSeq - NM_001358504
RefSeq - NM_001358506
RefSeq - NM_009306
RefSeq - XM_017313868
RefSeq - NM_001252341
RefSeq - NM_001252342
RefSeq - NM_001358501
RefSeq - XM_006513446
RefSeq - XM_006513447
RefSeq - XM_006513448
RefSeq - XM_006513449
RefSeq - XM_017313866
RefSeq - XM_017313867
RefSeq Peptide - NP_001345433
RefSeq Peptide - NP_033332
RefSeq Peptide - NP_001345432
RefSeq Peptide - NP_001345435
RefSeq Peptide - NP_001239270
RefSeq Peptide - NP_001239271
RefSeq Peptide - NP_001345430
RefSeq Peptide - NP_001345431
swissprot - P46096
swissprot - H6RXZ1
Ensembl - ENSMUSG00000035864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt1aENSDARG00000030614Danio rerio
 syt1bENSDARG00000042350Danio rerio
 SYT1ENSGALG00000041094Gallus gallus
 SYT1ENSG00000067715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syt2 / synaptotagmin II / Q8N9I0* / synaptotagmin 2*ENSMUSG0000002645277
Syt5 / Q9R0N5 / Synaptotagmin-5 / O00445*ENSMUSG0000000496153
Syt6 / Q9R0N8 / synaptotagmin VI / Q5T7P8* / synaptotagmin 6*ENSMUSG0000002784938
Syt10 / Q9R0N4 / synaptotagmin X / Q6XYQ8* / synaptotagmin 10*ENSMUSG0000006326037
Syt8 / Q9R0N6 / synaptotagmin VIII / Q8NBV8* / synaptotagmin 8*ENSMUSG0000003109836
Syt3 / synaptotagmin III / Q9BQG1* / synaptotagmin 3*ENSMUSG0000003073136
Syt9 / Q9R0N9 / Synaptotagmin-9 / Q86SS6*ENSMUSG0000006254236
Syt7 / Q9R0N7 / Synaptotagmin-7 / O43581*ENSMUSG0000002474334
Syt11 / Q9R0N3 / Synaptotagmin-11 / Q9BT88*ENSMUSG0000006892331
Syt4 / P40749 / Synaptotagmin-4 / Q9H2B2*ENSMUSG0000002426130


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR015428  Synaptotagmin 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005513 detection of calcium ion IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007269 neurotransmitter secretion IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0016079 synaptic vesicle exocytosis IMP
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0048278 vesicle docking IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0050806 positive regulation of synaptic transmission IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter IMP
 biological_processGO:1903305 regulation of regulated secretory pathway ISS
 biological_processGO:1903861 positive regulation of dendrite extension ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031045 dense core granule IDA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042584 chromaffin granule membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 molecular_functionGO:0000149 SNARE binding ISS
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding ISS
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding ISS
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0030348 syntaxin-3 binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IPI
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd274tm1.1Lex/Cd274tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Syt1tm3Sud/Syt1tm3Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002916 increased synaptic depression "increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Artm1Verh/Y,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003266 biliary cysts "the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Syt1tm3Sud/Syt1tm3Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008923 thoracoschisis "congenital fissure of the chest wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kif3atm1Gsn/Kif3a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013309 adrenal gland cyst "presence of fluid-filled usually benign growths in the adrenal gland" [MGI:Anna]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013528 thyroid cyst "presence of fluid-filled cavities (cysts) in the thyroid most commonly resulting from degenerating thyroid adenomas; often, solid components are mixed with fluid in thyroid cysts; thyroid cysts are usually benign, but they occasionally contain malignant solid components" [http://www.mayoclinic.org/diseases-conditions/thyroid-nodules/basics/causes/con-20021546, MGI:Anna]
Show

Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013967 abnormal infrahyoid muscle connection 
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013975 abnormal coronary sinus connection 
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020961 Ston2 / Q8BZ60 / Stonin-2 / Q8WXE9*  / reaction / complex
 ENSMUSG00000035864 Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*  / complex
 ENSMUSG00000070570 Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1 / Q9P2U7* / solute carrier family 17 member 7*  / complex
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / complex
 ENSMUSG00000100241 Slc18a3 / solute carrier family 18 member A3 / Q16572*  / complex / reaction






 

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