ENSMUSG00000004961


Mus musculus

Features
Gene ID: ENSMUSG00000004961
  
Biological name :Syt5
  
Synonyms : Q9R0N5 / Synaptotagmin-5 / Syt5
  
Possible biological names infered from orthology : O00445
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4539765
Gene end: 4547541
  
Corresponding Affymetrix probe sets: 10559580 (MoGene1.0st)   1422531_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145723
Ensembl peptide - ENSMUSP00000145980
Ensembl peptide - ENSMUSP00000070322
NCBI entrez gene - 53420     See in Manteia.
MGI - MGI:1926368
RefSeq - XM_006540189
RefSeq - XM_006540190
RefSeq - NM_016908
RefSeq Peptide - NP_058604
swissprot - Q9R0N5
swissprot - A0A0U1RPH1
swissprot - A0A0U1RNV9
Ensembl - ENSMUSG00000004961
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt5aENSDARG00000037941Danio rerio
 syt5bENSDARG00000011640Danio rerio
 SYT5ENSG00000129990Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*ENSMUSG0000003586458
Syt2 / synaptotagmin II / Q8N9I0* / synaptotagmin 2*ENSMUSG0000002645256
Syt6 / Q9R0N8 / synaptotagmin VI / Q5T7P8* / synaptotagmin 6*ENSMUSG0000002784941
Syt3 / synaptotagmin III / Q9BQG1* / synaptotagmin 3*ENSMUSG0000003073139
Syt8 / Q9R0N6 / synaptotagmin VIII / Q8NBV8* / synaptotagmin 8*ENSMUSG0000003109838
Syt9 / Q9R0N9 / Synaptotagmin-9 / Q86SS6*ENSMUSG0000006254238
Syt10 / Q9R0N4 / synaptotagmin X / Q6XYQ8* / synaptotagmin 10*ENSMUSG0000006326037
Syt7 / Q9R0N7 / Synaptotagmin-7 / O43581*ENSMUSG0000002474337
Syt4 / P40749 / Synaptotagmin-4 / Q9H2B2*ENSMUSG0000002426135
Syt11 / Q9R0N3 / Synaptotagmin-11 / Q9BT88*ENSMUSG0000006892335


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028689  Synaptotagmin-5
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 cellular_componentGO:0031045 dense core granule IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:1990769 proximal neuron projection IDA
 molecular_functionGO:0000149 SNARE binding IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrp1rgsc220/Tyrp1rgsc220
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mdm2tm1Bay/Mdm2+
Genetic Background: B6.129S7-Mdm2tm1Bay

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Bay/Mdm2+
Genetic Background: B6.129S7-Mdm2tm1Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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