ENSMUSG00000026452


Mus musculus

Features
Gene ID: ENSMUSG00000026452
  
Biological name :Syt2
  
Synonyms : synaptotagmin II / Syt2
  
Possible biological names infered from orthology : Q8N9I0 / synaptotagmin 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 134646677
Gene end: 134762593
  
Corresponding Affymetrix probe sets: 10350077 (MoGene1.0st)   1420418_at (Mouse Genome 430 2.0 Array)   1440323_at (Mouse Genome 430 2.0 Array)   1449866_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112438
Ensembl peptide - ENSMUSP00000140081
Ensembl peptide - ENSMUSP00000141156
NCBI entrez gene - 20980     See in Manteia.
MGI - MGI:99666
RefSeq - XM_006529324
RefSeq - NM_001355726
RefSeq - NM_009307
RefSeq - XM_006529322
RefSeq - XM_006529323
RefSeq Peptide - NP_001342655
RefSeq Peptide - NP_033333
swissprot - Q9JM87
swissprot - A0A0R4J2C2
Ensembl - ENSMUSG00000026452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYT2ENSDARG00000014169Danio rerio
 syt2aENSDARG00000025206Danio rerio
 SYT2ENSGALG00000026033Gallus gallus
 SYT2ENSG00000143858Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*ENSMUSG0000003586477
Syt5 / Q9R0N5 / Synaptotagmin-5 / O00445*ENSMUSG0000000496151
Syt6 / Q9R0N8 / synaptotagmin VI / Q5T7P8* / synaptotagmin 6*ENSMUSG0000002784937
Syt10 / Q9R0N4 / synaptotagmin X / Q6XYQ8* / synaptotagmin 10*ENSMUSG0000006326036
Syt7 / Q9R0N7 / Synaptotagmin-7 / O43581*ENSMUSG0000002474336
Syt8 / Q9R0N6 / synaptotagmin VIII / Q8NBV8* / synaptotagmin 8*ENSMUSG0000003109836
Syt3 / synaptotagmin III / Q9BQG1* / synaptotagmin 3*ENSMUSG0000003073135
Syt9 / Q9R0N9 / Synaptotagmin-9 / Q86SS6*ENSMUSG0000006254235
Syt4 / P40749 / Synaptotagmin-4 / Q9H2B2*ENSMUSG0000002426130
Syt11 / Q9R0N3 / Synaptotagmin-11 / Q9BT88*ENSMUSG0000006892330


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR015428  Synaptotagmin 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Socs7M1Btlr/Socs7+
Genetic Background: C57BL/6J-Socs7M1Btlr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

Allelic Composition: Syt2m1Btlr/Syt2m1Btlr
Genetic Background: C57BL/6J-Syt2m1Btlr

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ephx2tm1.1Arte/Ephx2tm1.1Arte,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Hand1tm1(tTA)Prri/Hand1+,Tg(tetO-Hand1)1Prri/0
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020961 Ston2 / Q8BZ60 / Stonin-2 / Q8WXE9*  / complex / reaction
 ENSMUSG00000026452 Syt2 / synaptotagmin II / Q8N9I0* / synaptotagmin 2*  / complex






 

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