ENSMUSG00000024743


Mus musculus

Features
Gene ID: ENSMUSG00000024743
  
Biological name :Syt7
  
Synonyms : Q9R0N7 / Synaptotagmin-7 / Syt7
  
Possible biological names infered from orthology : O43581
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 10389090
Gene end: 10453181
  
Corresponding Affymetrix probe sets: 10461459 (MoGene1.0st)   1423012_at (Mouse Genome 430 2.0 Array)   1439633_at (Mouse Genome 430 2.0 Array)   1441927_at (Mouse Genome 430 2.0 Array)   1460081_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153110
Ensembl peptide - ENSMUSP00000127973
Ensembl peptide - ENSMUSP00000153132
Ensembl peptide - ENSMUSP00000153482
Ensembl peptide - ENSMUSP00000073560
Ensembl peptide - ENSMUSP00000076234
NCBI entrez gene - 54525     See in Manteia.
MGI - MGI:1859545
RefSeq - XM_017318257
RefSeq - NM_173068
RefSeq - XM_006527204
RefSeq - XM_006527208
RefSeq - XM_017318252
RefSeq - XM_017318253
RefSeq - XM_017318254
RefSeq - XM_017318255
RefSeq - NM_018801
RefSeq - NM_173067
RefSeq Peptide - NP_775091
RefSeq Peptide - NP_061271
RefSeq Peptide - NP_775090
swissprot - A0A286YCR9
swissprot - Q9R0N7
swissprot - A0A286YCU4
swissprot - A0A2C9F2C1
Ensembl - ENSMUSG00000024743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt7aENSDARG00000063568Danio rerio
 syt7bENSDARG00000078060Danio rerio
 SYT7ENSGALG00000043139Gallus gallus
 SYT7ENSG00000011347Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syt2 / synaptotagmin II / Q8N9I0* / synaptotagmin 2*ENSMUSG0000002645227
Syt6 / Q9R0N8 / synaptotagmin VI / Q5T7P8* / synaptotagmin 6*ENSMUSG0000002784927
Syt9 / Q9R0N9 / Synaptotagmin-9 / Q86SS6*ENSMUSG0000006254227
Syt3 / synaptotagmin III / Q9BQG1* / synaptotagmin 3*ENSMUSG0000003073126
Syt11 / Q9R0N3 / Synaptotagmin-11 / Q9BT88*ENSMUSG0000006892326
Syt4 / P40749 / Synaptotagmin-4 / Q9H2B2*ENSMUSG0000002426126
Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*ENSMUSG0000003586425
Syt10 / Q9R0N4 / synaptotagmin X / Q6XYQ8* / synaptotagmin 10*ENSMUSG0000006326025
Syt5 / Q9R0N5 / Synaptotagmin-5 / O00445*ENSMUSG0000000496125
Syt8 / Q9R0N6 / synaptotagmin VIII / Q8NBV8* / synaptotagmin 8*ENSMUSG0000003109819


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR015427  Synaptotagmin 7
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001778 plasma membrane repair IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0017156 calcium ion regulated exocytosis IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0036465 synaptic vesicle recycling IMP
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IMP
 biological_processGO:0050764 regulation of phagocytosis IMP
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0070092 regulation of glucagon secretion IMP
 biological_processGO:0090119 vesicle-mediated cholesterol transport IDA
 biological_processGO:0090385 phagosome-lysosome fusion IMP
 biological_processGO:1990926 short-term synaptic potentiation IMP
 biological_processGO:1990927 calcium ion regulated lysosome exocytosis IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000149 SNARE binding IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IDA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ing1Gt(OST206270)Lex/Ing1+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Syt7tm2Sud/Syt7tm2Sud
Genetic Background: B6.129-Syt7tm1Sud

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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