ENSMUSG00000068923


Mus musculus

Features
Gene ID: ENSMUSG00000068923
  
Biological name :Syt11
  
Synonyms : Q9R0N3 / Synaptotagmin-11 / Syt11
  
Possible biological names infered from orthology : Q9BT88
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 88744700
Gene end: 88775164
  
Corresponding Affymetrix probe sets: 10499431 (MoGene1.0st)   1429314_at (Mouse Genome 430 2.0 Array)   1429315_at (Mouse Genome 430 2.0 Array)   1449264_at (Mouse Genome 430 2.0 Array)   1455176_a_at (Mouse Genome 430 2.0 Array)   1456464_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138284
Ensembl peptide - ENSMUSP00000088464
Ensembl peptide - ENSMUSP00000103127
Ensembl peptide - ENSMUSP00000103129
NCBI entrez gene - 229521     See in Manteia.
MGI - MGI:1859547
RefSeq - XM_006501348
RefSeq - XM_006501350
RefSeq - NM_018804
RefSeq Peptide - NP_061274
swissprot - Q9R0N3
swissprot - D3YWW9
swissprot - S4R1M8
Ensembl - ENSMUSG00000068923
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt11aENSDARG00000057913Danio rerio
 syt11bENSDARG00000056105Danio rerio
 SYT11ENSGALG00000014646Gallus gallus
 SYT11ENSG00000132718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syt4 / P40749 / Synaptotagmin-4 / Q9H2B2*ENSMUSG0000002426154
Syt7 / Q9R0N7 / Synaptotagmin-7 / O43581*ENSMUSG0000002474334
Syt6 / Q9R0N8 / synaptotagmin VI / Q5T7P8* / synaptotagmin 6*ENSMUSG0000002784932
Syt5 / Q9R0N5 / Synaptotagmin-5 / O00445*ENSMUSG0000000496131
Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*ENSMUSG0000003586430
Syt10 / Q9R0N4 / synaptotagmin X / Q6XYQ8* / synaptotagmin 10*ENSMUSG0000006326030
Syt2 / synaptotagmin II / Q8N9I0* / synaptotagmin 2*ENSMUSG0000002645229
Syt9 / Q9R0N9 / Synaptotagmin-9 / Q86SS6*ENSMUSG0000006254229
Syt3 / synaptotagmin III / Q9BQG1* / synaptotagmin 3*ENSMUSG0000003073128
Syt8 / Q9R0N6 / synaptotagmin VIII / Q8NBV8* / synaptotagmin 8*ENSMUSG0000003109824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028699  Synaptotagmin-11
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001778 plasma membrane repair IMP
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IMP
 biological_processGO:1900186 negative regulation of clathrin-dependent endocytosis IEA
 biological_processGO:1900243 negative regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1900424 regulation of defense response to bacterium IMP
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IMP
 biological_processGO:1905154 negative regulation of membrane invagination IEA
 biological_processGO:1905162 regulation of phagosome maturation TAS
 biological_processGO:1905171 positive regulation of protein localization to phagocytic vesicle IMP
 biological_processGO:1905469 negative regulation of clathrin-coated pit assembly IEA
 biological_processGO:1990927 calcium ion regulated lysosome exocytosis IMP
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000149 SNARE binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0031369 translation initiation factor binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IPI


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000068923 Syt11 / Q9R0N3 / Synaptotagmin-11 / Q9BT88*  / complex






 

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