ENSG00000132718


Homo sapiens

Features
Gene ID: ENSG00000132718
  
Biological name :SYT11
  
Synonyms : Q9BT88 / synaptotagmin 11 / SYT11
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q22
Gene start: 155859509
Gene end: 155885199
  
Corresponding Affymetrix probe sets: 209197_at (Human Genome U133 Plus 2.0 Array)   209198_s_at (Human Genome U133 Plus 2.0 Array)   232677_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357307
NCBI entrez gene - 23208     See in Manteia.
OMIM - 608741
RefSeq - XM_017000759
RefSeq - NM_152280
RefSeq - XM_005245014
RefSeq Peptide - NP_689493
swissprot - Q9BT88
Ensembl - ENSG00000132718
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt11aENSDARG00000057913Danio rerio
 syt11bENSDARG00000056105Danio rerio
 SYT11ENSGALG00000014646Gallus gallus
 Syt11ENSMUSG00000068923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT4 / Q9H2B2 / synaptotagmin 4ENSG0000013287252
SYT7 / O43581 / synaptotagmin 7ENSG0000001134733
SYT1 / P21579 / synaptotagmin 1ENSG0000006771530
SYT10 / Q6XYQ8 / synaptotagmin 10ENSG0000011097530
SYT5 / O00445 / synaptotagmin 5ENSG0000012999030
SYT6 / Q5T7P8 / synaptotagmin 6ENSG0000013420729
SYT3 / Q9BQG1 / synaptotagmin 3ENSG0000021302329
SYT2 / Q8N9I0 / synaptotagmin 2ENSG0000014385829
SYT9 / Q86SS6 / synaptotagmin 9ENSG0000017074328
SYT8 / Q8NBV8 / synaptotagmin 8ENSG0000014904325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028699  Synaptotagmin-11
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001778 plasma membrane repair IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0046929 negative regulation of neurotransmitter secretion TAS
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:1900186 negative regulation of clathrin-dependent endocytosis IEA
 biological_processGO:1900243 negative regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1900424 regulation of defense response to bacterium IEA
 biological_processGO:1904468 negative regulation of tumor necrosis factor secretion IEA
 biological_processGO:1905154 negative regulation of membrane invagination IEA
 biological_processGO:1905162 regulation of phagosome maturation IC
 biological_processGO:1905171 positive regulation of protein localization to phagocytic vesicle IEA
 biological_processGO:1905469 negative regulation of clathrin-coated pit assembly IEA
 biological_processGO:1990927 calcium ion regulated lysosome exocytosis IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032009 early phagosome IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0048787 presynaptic active zone membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132718 SYT11 / Q9BT88 / synaptotagmin 11  / complex






 

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