ENSG00000149043


Homo sapiens

Features
Gene ID: ENSG00000149043
  
Biological name :SYT8
  
Synonyms : Q8NBV8 / synaptotagmin 8 / SYT8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 1828307
Gene end: 1837521
  
Corresponding Affymetrix probe sets: 232802_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371406
Ensembl peptide - ENSP00000371394
Ensembl peptide - ENSP00000387678
Ensembl peptide - ENSP00000405850
Ensembl peptide - ENSP00000392469
Ensembl peptide - ENSP00000343691
NCBI entrez gene - 90019     See in Manteia.
OMIM - 607719
RefSeq - XM_017018529
RefSeq - NM_001290332
RefSeq - NM_001290333
RefSeq - NM_001290334
RefSeq - NM_138567
RefSeq - XM_011520455
RefSeq - XM_011520456
RefSeq - XM_011520457
RefSeq - XM_017018528
RefSeq Peptide - NP_001277263
RefSeq Peptide - NP_612634
RefSeq Peptide - NP_001277262
RefSeq Peptide - NP_001277261
swissprot - H0Y3G9
swissprot - Q8NBV8
swissprot - A6NCR4
swissprot - C9K032
swissprot - C9J253
swissprot - F8WBL4
Ensembl - ENSG00000149043
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SYT8ENSGALG00000006602Gallus gallus
 Syt8ENSMUSG00000031098Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT2 / Q8N9I0 / synaptotagmin 2ENSG0000014385840
SYT5 / O00445 / synaptotagmin 5ENSG0000012999040
SYT1 / P21579 / synaptotagmin 1ENSG0000006771539
SYT9 / Q86SS6 / synaptotagmin 9ENSG0000017074329
SYT10 / Q6XYQ8 / synaptotagmin 10ENSG0000011097528
SYT3 / Q9BQG1 / synaptotagmin 3ENSG0000021302328
SYT4 / Q9H2B2 / synaptotagmin 4ENSG0000013287226
SYT7 / O43581 / synaptotagmin 7ENSG0000001134726
SYT11 / Q9BT88 / synaptotagmin 11ENSG0000013271826
SYT6 / Q5T7P8 / synaptotagmin 6ENSG0000013420725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR030540  Synaptotagmin-8
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007340 acrosome reaction IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149043 SYT8 / Q8NBV8 / synaptotagmin 8  / complex






 

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