ENSG00000129990


Homo sapiens

Features
Gene ID: ENSG00000129990
  
Biological name :SYT5
  
Synonyms : O00445 / synaptotagmin 5 / SYT5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.42
Gene start: 55171199
Gene end: 55180441
  
Corresponding Affymetrix probe sets: 206161_s_at (Human Genome U133 Plus 2.0 Array)   206162_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467685
Ensembl peptide - ENSP00000465576
Ensembl peptide - ENSP00000469874
Ensembl peptide - ENSP00000346265
Ensembl peptide - ENSP00000442896
Ensembl peptide - ENSP00000465074
Ensembl peptide - ENSP00000465110
Ensembl peptide - ENSP00000465304
NCBI entrez gene - 6861     See in Manteia.
OMIM - 600782
RefSeq - XM_017027176
RefSeq - NM_001297774
RefSeq - NM_003180
RefSeq - XM_006723339
RefSeq - XM_006723340
RefSeq - XM_006723341
RefSeq - XM_017027175
RefSeq Peptide - NP_001284703
RefSeq Peptide - NP_003171
swissprot - K7EJC4
swissprot - K7EJS7
swissprot - K7EQ59
swissprot - M0QYJ7
swissprot - A0A024R4N8
swissprot - O00445
swissprot - K7EJ95
Ensembl - ENSG00000129990
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt5aENSDARG00000037941Danio rerio
 syt5bENSDARG00000011640Danio rerio
 Syt5ENSMUSG00000004961Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT1 / P21579 / synaptotagmin 1ENSG0000006771559
SYT2 / Q8N9I0 / synaptotagmin 2ENSG0000014385859
SYT8 / Q8NBV8 / synaptotagmin 8ENSG0000014904342
SYT3 / Q9BQG1 / synaptotagmin 3ENSG0000021302340
SYT6 / Q5T7P8 / synaptotagmin 6ENSG0000013420739
SYT9 / Q86SS6 / synaptotagmin 9ENSG0000017074338
SYT10 / Q6XYQ8 / synaptotagmin 10ENSG0000011097537
SYT7 / O43581 / synaptotagmin 7ENSG0000001134735
SYT11 / Q9BT88 / synaptotagmin 11ENSG0000013271834
SYT4 / Q9H2B2 / synaptotagmin 4ENSG0000013287233


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028689  Synaptotagmin-5
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IBA
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:1990769 proximal neuron projection IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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