ENSG00000067715


Homo sapiens

Features
Gene ID: ENSG00000067715
  
Biological name :SYT1
  
Synonyms : P21579 / synaptotagmin 1 / SYT1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q21.2
Gene start: 78863993
Gene end: 79452008
  
Corresponding Affymetrix probe sets: 203998_s_at (Human Genome U133 Plus 2.0 Array)   203999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448861
Ensembl peptide - ENSP00000447656
Ensembl peptide - ENSP00000448964
Ensembl peptide - ENSP00000450321
Ensembl peptide - ENSP00000261205
Ensembl peptide - ENSP00000376932
Ensembl peptide - ENSP00000391056
Ensembl peptide - ENSP00000401559
Ensembl peptide - ENSP00000447035
Ensembl peptide - ENSP00000447575
NCBI entrez gene - 6857     See in Manteia.
OMIM - 185605
RefSeq - XM_017019909
RefSeq - NM_001135805
RefSeq - NM_001135806
RefSeq - NM_001291901
RefSeq - NM_005639
RefSeq - XM_005269113
RefSeq - XM_006719576
RefSeq - XM_011538710
RefSeq Peptide - NP_005630
RefSeq Peptide - NP_001129277
RefSeq Peptide - NP_001129278
RefSeq Peptide - NP_001278830
swissprot - J3KQA0
swissprot - C9JX50
swissprot - F8VXH0
swissprot - F8VYH8
swissprot - F8VZY3
swissprot - P21579
swissprot - A0A024RBE9
swissprot - F8W1U9
Ensembl - ENSG00000067715
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt1aENSDARG00000030614Danio rerio
 syt1bENSDARG00000042350Danio rerio
 SYT1ENSGALG00000041094Gallus gallus
 Syt1ENSMUSG00000035864Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT2 / Q8N9I0 / synaptotagmin 2ENSG0000014385877
SYT5 / O00445 / synaptotagmin 5ENSG0000012999054
SYT10 / Q6XYQ8 / synaptotagmin 10ENSG0000011097538
SYT8 / Q8NBV8 / synaptotagmin 8ENSG0000014904337
SYT9 / Q86SS6 / synaptotagmin 9ENSG0000017074336
SYT3 / Q9BQG1 / synaptotagmin 3ENSG0000021302336
SYT6 / Q5T7P8 / synaptotagmin 6ENSG0000013420736
SYT7 / O43581 / synaptotagmin 7ENSG0000001134734
SYT4 / Q9H2B2 / synaptotagmin 4ENSG0000013287231
SYT11 / Q9BT88 / synaptotagmin 11ENSG0000013271830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR015428  Synaptotagmin 1/2
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005513 detection of calcium ion TAS
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0014047 glutamate secretion TAS
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IEA
 biological_processGO:0017157 regulation of exocytosis TAS
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0048278 vesicle docking IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IBA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050806 positive regulation of synaptic transmission ISS
 biological_processGO:0051260 protein homooligomerization TAS
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter ISS
 biological_processGO:1903305 regulation of regulated secretory pathway ISS
 biological_processGO:1903861 positive regulation of dendrite extension IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0030672 synaptic vesicle membrane TAS
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042584 chromaffin granule membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane TAS
 cellular_componentGO:0060203 clathrin-sculpted glutamate transport vesicle membrane TAS
 cellular_componentGO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane TAS
 cellular_componentGO:0070083 clathrin-sculpted monoamine transport vesicle membrane TAS
 molecular_functionGO:0000149 SNARE binding ISS
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0005545 1-phosphatidylinositol binding TAS
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding ISS
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0030348 syntaxin-3 binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IDA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Toxicity of botulinum toxin type B (BoNT/B)
Toxicity of botulinum toxin type G (BoNT/G)
Neurexins and neuroligins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105649 RAB3A / P20336 / RAB3A, member RAS oncogene family  / complex
 ENSG00000187714 Q16572 / SLC18A3 / solute carrier family 18 member A3  / complex / reaction
 ENSG00000220205 VAMP2 / P63027 / vesicle associated membrane protein 2  / complex
 ENSG00000140022 STON2 / Q8WXE9 / stonin 2  / complex / reaction
 ENSG00000067715 SYT1 / P21579 / synaptotagmin 1  / complex
 ENSG00000104888 Q9P2U7 / SLC17A7 / solute carrier family 17 member 7  / complex






 

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