ENSG00000132872


Homo sapiens

Features
Gene ID: ENSG00000132872
  
Biological name :SYT4
  
Synonyms : Q9H2B2 / synaptotagmin 4 / SYT4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q12.3
Gene start: 43267878
Gene end: 43277650
  
Corresponding Affymetrix probe sets: 223529_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472583
Ensembl peptide - ENSP00000255224
Ensembl peptide - ENSP00000466930
Ensembl peptide - ENSP00000470516
NCBI entrez gene - 6860     See in Manteia.
OMIM - 600103
RefSeq - NM_020783
RefSeq Peptide - NP_065834
swissprot - M0QZF3
swissprot - M0R2I0
swissprot - Q9H2B2
Ensembl - ENSG00000132872
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt4ENSDARG00000036505Danio rerio
 SYT4ENSGALG00000042626Gallus gallus
 Syt4ENSMUSG00000024261Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SYT11 / Q9BT88 / synaptotagmin 11ENSG0000013271853
SYT10 / Q6XYQ8 / synaptotagmin 10ENSG0000011097532
SYT2 / Q8N9I0 / synaptotagmin 2ENSG0000014385832
SYT7 / O43581 / synaptotagmin 7ENSG0000001134732
SYT9 / Q86SS6 / synaptotagmin 9ENSG0000017074331
SYT5 / O00445 / synaptotagmin 5ENSG0000012999030
SYT6 / Q5T7P8 / synaptotagmin 6ENSG0000013420730
SYT1 / P21579 / synaptotagmin 1ENSG0000006771530
SYT3 / Q9BQG1 / synaptotagmin 3ENSG0000021302329
SYT8 / Q8NBV8 / synaptotagmin 8ENSG0000014904324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028683  Synaptotagmin-4
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0007269 neurotransmitter secretion IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0014049 positive regulation of glutamate secretion IEA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0030100 regulation of endocytosis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031338 regulation of vesicle fusion IEA
 biological_processGO:0031339 negative regulation of vesicle fusion IEA
 biological_processGO:0033604 negative regulation of catecholamine secretion IGI
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis NAS
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis NAS
 biological_processGO:0046929 negative regulation of neurotransmitter secretion IEA
 biological_processGO:0048174 negative regulation of short-term neuronal synaptic plasticity IEA
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0061782 vesicle fusion with vesicle IEA
 biological_processGO:0061792 secretory granule maturation IEA
 biological_processGO:1903861 positive regulation of dendrite extension IDA
 biological_processGO:1905433 negative regulation of retrograde trans-synaptic signaling by neuropeptide IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030173 integral component of Golgi membrane NAS
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane NAS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0032127 dense core granule membrane NAS
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070382 exocytic vesicle IEA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:1990742 microvesicle IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0019905 syntaxin binding IBA
 molecular_functionGO:0030276 clathrin binding IBA
 molecular_functionGO:0030348 syntaxin-3 binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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