ENSMUSG00000024261


Mus musculus

Features
Gene ID: ENSMUSG00000024261
  
Biological name :Syt4
  
Synonyms : P40749 / Synaptotagmin-4 / Syt4
  
Possible biological names infered from orthology : Q9H2B2
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B1
Gene start: 31437808
Gene end: 31447415
  
Corresponding Affymetrix probe sets: 10457942 (MoGene1.0st)   1415844_at (Mouse Genome 430 2.0 Array)   1415845_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025110
NCBI entrez gene - 20983     See in Manteia.
MGI - MGI:101759
RefSeq - NM_009308
RefSeq - XM_017317852
RefSeq Peptide - NP_033334
swissprot - P40749
Ensembl - ENSMUSG00000024261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 syt4ENSDARG00000036505Danio rerio
 SYT4ENSGALG00000042626Gallus gallus
 SYT4ENSG00000132872Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Syt11 / Q9R0N3 / Synaptotagmin-11 / Q9BT88*ENSMUSG0000006892355
Syt7 / Q9R0N7 / Synaptotagmin-7 / O43581*ENSMUSG0000002474334
Syt5 / Q9R0N5 / Synaptotagmin-5 / O00445*ENSMUSG0000000496132
Syt10 / Q9R0N4 / synaptotagmin X / Q6XYQ8* / synaptotagmin 10*ENSMUSG0000006326030
Syt6 / Q9R0N8 / synaptotagmin VI / Q5T7P8* / synaptotagmin 6*ENSMUSG0000002784930
Syt2 / synaptotagmin II / Q8N9I0* / synaptotagmin 2*ENSMUSG0000002645230
Syt9 / Q9R0N9 / Synaptotagmin-9 / Q86SS6*ENSMUSG0000006254230
Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*ENSMUSG0000003586430
Syt3 / synaptotagmin III / Q9BQG1* / synaptotagmin 3*ENSMUSG0000003073129
Syt8 / Q9R0N6 / synaptotagmin VIII / Q8NBV8* / synaptotagmin 8*ENSMUSG0000003109824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001565  Synaptotagmin
 IPR028683  Synaptotagmin-4
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0007269 neurotransmitter secretion IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0014049 positive regulation of glutamate secretion IMP
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis TAS
 biological_processGO:0030100 regulation of endocytosis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031338 regulation of vesicle fusion IMP
 biological_processGO:0031339 negative regulation of vesicle fusion IEA
 biological_processGO:0033604 negative regulation of catecholamine secretion IEA
 biological_processGO:0045955 negative regulation of calcium ion-dependent exocytosis IEA
 biological_processGO:0046929 negative regulation of neurotransmitter secretion IEA
 biological_processGO:0048174 negative regulation of short-term neuronal synaptic plasticity IMP
 biological_processGO:0048489 synaptic vesicle transport TAS
 biological_processGO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA
 biological_processGO:0050709 negative regulation of protein secretion IMP
 biological_processGO:0061782 vesicle fusion with vesicle IEA
 biological_processGO:0061792 secretory granule maturation IEA
 biological_processGO:1903861 positive regulation of dendrite extension IEA
 biological_processGO:1905414 negative regulation of dense core granule exocytosis IEA
 biological_processGO:1905415 positive regulation of dense core granule exocytosis IMP
 biological_processGO:1905433 negative regulation of retrograde trans-synaptic signaling by neuropeptide IMP
 biological_processGO:2000301 negative regulation of synaptic vesicle exocytosis IMP
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031045 dense core granule IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070382 exocytic vesicle IEA
 cellular_componentGO:0097449 astrocyte projection IDA
 cellular_componentGO:0098793 presynapse NAS
 cellular_componentGO:0098794 postsynapse NAS
 cellular_componentGO:1990742 microvesicle IDA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IDA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0019905 syntaxin binding IEA
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0030348 syntaxin-3 binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
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Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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