ENSMUSG00000070570


Mus musculus

Features
Gene ID: ENSMUSG00000070570
  
Biological name :Slc17a7
  
Synonyms : Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1
  
Possible biological names infered from orthology : Q9P2U7 / solute carrier family 17 member 7
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45163949
Gene end: 45176142
  
Corresponding Affymetrix probe sets: 10552857 (MoGene1.0st)   1428986_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147661
Ensembl peptide - ENSMUSP00000082489
NCBI entrez gene - 72961     See in Manteia.
MGI - MGI:1920211
RefSeq - NM_182993
RefSeq Peptide - NP_892038
swissprot - A0A1B0GRU0
swissprot - Q3TXX4
Ensembl - ENSMUSG00000070570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc17a7aENSDARG00000016480Danio rerio
 slc17a7bENSDARG00000090106Danio rerio
 Q9P2U7ENSG00000104888Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc17a6 / solute carrier family 17 member 6 / Q9P2U8*ENSMUSG0000003050077
Q8BFU8 / Slc17a8 / Vesicular glutamate transporter 3 / Q8NDX2* / solute carrier family 17 member 8*ENSMUSG0000001993574
Q8BN82 / Sialin / Slc17a5 / Q9NRA2* / solute carrier family 17 member 5*ENSMUSG0000004962433
Slc17a3 / solute carrier family 17 (sodium phosphate), member 3 / O00476* / solute carrier family 17 member 3*ENSMUSG0000003608326
Q5NCM1 / Slc17a4 / Probable small intestine urate exporter / Q9Y2C5* / solute carrier family 17 member 4*ENSMUSG0000002133625
Q61983 / Slc17a1 / solute carrier family 17 (sodium phosphate), member 1 / Q14916* / solute carrier family 17 member 1*ENSMUSG0000002133525
Q5SZA1 / Slc17a2 / solute carrier family 17 (sodium phosphate), member 2 / O00624* / solute carrier family 17 member 2*ENSMUSG0000003611023
Q8VCL5 / Slc17a9 / solute carrier family 17, member 9 / Q9BYT1*ENSMUSG0000002339322


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006817 phosphate ion transport IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0035249 synaptic transmission, glutamatergic IMP
 biological_processGO:0035725 sodium ion transmembrane transport IBA
 biological_processGO:0042137 sequestering of neurotransmitter IMP
 biological_processGO:0044341 sodium-dependent phosphate transport IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051938 L-glutamate import IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:0097401 synaptic vesicle lumen acidification IMP
 biological_processGO:0098700 neurotransmitter loading into synaptic vesicle IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0044300 cerebellar mossy fiber IDA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048786 presynaptic active zone IDA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0005315 inorganic phosphate transmembrane transporter activity IEA
 molecular_functionGO:0008068 extracellularly glutamate-gated chloride channel activity IDA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015319 sodium:inorganic phosphate symporter activity IEA
 molecular_functionGO:0015321 sodium-dependent phosphate transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Glutamate Neurotransmitter Release Cycle
Organic anion transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Kcnn2bc-9J/Kcnn2bc-9J
Genetic Background: C57BL/6J-bc9J/GrsrJ

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Slc17a7tm1Rmnd/Slc17a7tm1Rmnd
Genetic Background: involves: 129P2/OlaHsd

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Red/Gt(ROSA)26Sor+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Slc17a7tm1Rmnd/Slc17a7tm1Rmnd
Genetic Background: involves: 129P2/OlaHsd

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003444 abnormal neurotransmitter uptake "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Eportm1(EGFP/cre)Uk/Eportm1(EGFP/cre)Uk
Genetic Background: involves: BALB/cJ

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a7tm1Rmnd/Slc17a7tm1Rmnd
Genetic Background: involves: 129P2/OlaHsd

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc17a7tm1Edw/Slc17a7tm1Edw
Genetic Background: involves: 129X1/SvJ

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Slc17a7tm1Rmnd/Slc17a7tm1Rmnd
Genetic Background: involves: 129P2/OlaHsd

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
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Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / complex
 ENSMUSG00000035864 Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*  / complex






 

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