ENSMUSG00000049624


Mus musculus

Features
Gene ID: ENSMUSG00000049624
  
Biological name :Slc17a5
  
Synonyms : Q8BN82 / Sialin / Slc17a5
  
Possible biological names infered from orthology : Q9NRA2 / solute carrier family 17 member 5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E1
Gene start: 78536488
Gene end: 78588041
  
Corresponding Affymetrix probe sets: 10595189 (MoGene1.0st)   1429116_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056182
Ensembl peptide - ENSMUSP00000113003
NCBI entrez gene - 235504     See in Manteia.
MGI - MGI:1924105
RefSeq - XM_017313345
RefSeq - NM_001276452
RefSeq - NM_172773
RefSeq - XM_006511128
RefSeq - XM_011242737
RefSeq Peptide - NP_001263381
RefSeq Peptide - NP_766361
swissprot - Q8BN82
Ensembl - ENSMUSG00000049624
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc17a5ENSDARG00000055190Danio rerio
 SLC17A5ENSGALG00000015916Gallus gallus
 Q9NRA2ENSG00000119899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc17a6 / solute carrier family 17 member 6 / Q9P2U8*ENSMUSG0000003050040
Q8BFU8 / Slc17a8 / Vesicular glutamate transporter 3 / Q8NDX2* / solute carrier family 17 member 8*ENSMUSG0000001993538
Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1 / Q9P2U7* / solute carrier family 17 member 7*ENSMUSG0000007057037
Slc17a3 / solute carrier family 17 (sodium phosphate), member 3 / O00476* / solute carrier family 17 member 3*ENSMUSG0000003608334
Q5NCM1 / Slc17a4 / Probable small intestine urate exporter / Q9Y2C5* / solute carrier family 17 member 4*ENSMUSG0000002133634
Q5SZA1 / Slc17a2 / solute carrier family 17 (sodium phosphate), member 2 / O00624* / solute carrier family 17 member 2*ENSMUSG0000003611033
Q61983 / Slc17a1 / solute carrier family 17 (sodium phosphate), member 1 / Q14916* / solute carrier family 17 member 1*ENSMUSG0000002133533
Q8VCL5 / Slc17a9 / solute carrier family 17, member 9 / Q9BYT1*ENSMUSG0000002339324


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006865 amino acid transport IEA
 biological_processGO:0015739 sialic acid transport IBA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005764 lysosome IBA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0015136 sialic acid transmembrane transporter activity IBA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Sialic acid metabolism
Organic anion transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0000954 reduced oligodendrocyte progenitor number "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc12a6Gt(OST458419)Lex/Slc12a6Gt(OST458419)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc17a5tm1Lex/Slc17a5tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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