ENSMUSG00000019935


Mus musculus

Features
Gene ID: ENSMUSG00000019935
  
Biological name :Slc17a8
  
Synonyms : Q8BFU8 / Slc17a8 / Vesicular glutamate transporter 3
  
Possible biological names infered from orthology : Q8NDX2 / solute carrier family 17 member 8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 89574020
Gene end: 89621253
  
Corresponding Affymetrix probe sets: 10371796 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000020102
Ensembl peptide - ENSMUSP00000100932
NCBI entrez gene - 216227     See in Manteia.
MGI - MGI:3039629
RefSeq - NM_001310710
RefSeq - NM_182959
RefSeq Peptide - NP_001297639
RefSeq Peptide - NP_892004
swissprot - Q8BFU8
swissprot - D3YTT3
Ensembl - ENSMUSG00000019935
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q1L8X9ENSDARG00000057728Danio rerio
 SLC17A8ENSGALG00000041122Gallus gallus
 Q8NDX2ENSG00000179520Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc17a6 / solute carrier family 17 member 6 / Q9P2U8*ENSMUSG0000003050070
Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1 / Q9P2U7* / solute carrier family 17 member 7*ENSMUSG0000007057069
Q8BN82 / Sialin / Slc17a5 / Q9NRA2* / solute carrier family 17 member 5*ENSMUSG0000004962431
Slc17a3 / solute carrier family 17 (sodium phosphate), member 3 / O00476* / solute carrier family 17 member 3*ENSMUSG0000003608324
Q5NCM1 / Slc17a4 / Probable small intestine urate exporter / Q9Y2C5* / solute carrier family 17 member 4*ENSMUSG0000002133624
Q61983 / Slc17a1 / solute carrier family 17 (sodium phosphate), member 1 / Q14916* / solute carrier family 17 member 1*ENSMUSG0000002133523
Q5SZA1 / Slc17a2 / solute carrier family 17 (sodium phosphate), member 2 / O00624* / solute carrier family 17 member 2*ENSMUSG0000003611022
Q8VCL5 / Slc17a9 / solute carrier family 17, member 9 / Q9BYT1*ENSMUSG0000002339320


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR027378  Cyclic nucleotide-regulated ion channel, N-terminal
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0015813 L-glutamate transmembrane transport IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0090102 cochlea development IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0097440 apical dendrite IEA
 cellular_componentGO:0097441 basal dendrite IEA
 cellular_componentGO:0097451 glial limiting end-foot IEA
 cellular_componentGO:1990030 pericellular basket IEA
 molecular_functionGO:0005313 L-glutamate transmembrane transporter activity IDA
 molecular_functionGO:0015293 symporter activity IEA


Pathways (from Reactome)
Pathway description
Organic anion transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000948 nonconvulsive seizures "seizures without uncontrolled motor activity, but with impairment of consciousness" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: F5tm2Dgi/F5+,Serpina10tm1Gjb/Serpina10tm1Gjb
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0003444 abnormal neurotransmitter uptake "aberration in the reabsorbtion of endogenous signaling molecules normally taken in by neurons that alter the behavior of neurons or effector cells" [J:95639, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004416 absent cochlear nerve compound action potential "absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004433 abnormal cochlear inner hair cell physiology "anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0004562 abnormal inner hair cell synaptic ribbon morphology "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004633 abnormal cochlear IHC efferent innervation "any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0004836 abnormal synaptic acetylcholine release "aberrant secretion across synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc17a8tm1Edw/Slc17a8+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0009253 abnormal sympathetic neuron physiology "any functional anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Dmbt1tm1Kumc/Dmbt1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

Allelic Composition: Slc17a8tm1Selm/Slc17a8tm1Selm
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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