ENSMUSG00000030500


Mus musculus

Features
Gene ID: ENSMUSG00000030500
  
Biological name :Slc17a6
  
Synonyms : Slc17a6 / solute carrier family 17 member 6
  
Possible biological names infered from orthology : Q9P2U8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B4
Gene start: 51622006
Gene end: 51671119
  
Corresponding Affymetrix probe sets: 10553501 (MoGene1.0st)   1418610_at (Mouse Genome 430 2.0 Array)   1428379_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032710
Ensembl peptide - ENSMUSP00000146364
NCBI entrez gene - 140919     See in Manteia.
MGI - MGI:2156052
RefSeq - NM_080853
RefSeq - XM_006540601
RefSeq - XM_006540602
RefSeq Peptide - NP_543129
swissprot - A0A140LHC9
swissprot - A0A0R4J0A6
Ensembl - ENSMUSG00000030500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5W8I8ENSDARG00000041150Danio rerio
 slc17a6aENSDARG00000001127Danio rerio
 SLC17A6ENSGALG00000039254Gallus gallus
 Q9P2U8ENSG00000091664Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1 / Q9P2U7* / solute carrier family 17 member 7*ENSMUSG0000007057074
Q8BFU8 / Slc17a8 / Vesicular glutamate transporter 3 / Q8NDX2* / solute carrier family 17 member 8*ENSMUSG0000001993572
Q8BN82 / Sialin / Slc17a5 / Q9NRA2* / solute carrier family 17 member 5*ENSMUSG0000004962434
Slc17a3 / solute carrier family 17 (sodium phosphate), member 3 / O00476* / solute carrier family 17 member 3*ENSMUSG0000003608326
Q5NCM1 / Slc17a4 / Probable small intestine urate exporter / Q9Y2C5* / solute carrier family 17 member 4*ENSMUSG0000002133625
Q61983 / Slc17a1 / solute carrier family 17 (sodium phosphate), member 1 / Q14916* / solute carrier family 17 member 1*ENSMUSG0000002133524
Q5SZA1 / Slc17a2 / solute carrier family 17 (sodium phosphate), member 2 / O00624* / solute carrier family 17 member 2*ENSMUSG0000003611023
Q8VCL5 / Slc17a9 / solute carrier family 17, member 9 / Q9BYT1*ENSMUSG0000002339320


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0098700 neurotransmitter loading into synaptic vesicle IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098793 presynapse IEA


Pathways (from Reactome)
Pathway description
Organic anion transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Uchl1tm1Dgen/Uchl1tm1Dgen
Genetic Background: B6.129P2-Uchl1tm1Dgen/Mmnc

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Uchl1tm1Dgen/Uchl1tm1Dgen
Genetic Background: B6.129P2-Uchl1tm1Dgen/Mmnc

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Slc17a6tm1.1Thna/Slc17a6tm1.1Thna
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Rai1tm2.1Luo/Rai1+,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Rai1tm2.1Luo/Rai1+,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Socs1tm1Ayos/Socs1tm1Ayos,Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Tg(PLAT-cre)116Sdu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Tg(Trpv1-icre)1Kldr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Grprtm1Jfb/Grprtm1Jfb,Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Grin1tm2Stl/Grin1tm2Stl
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Tg(Sim1-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Tg(PLAT-cre)116Sdu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Tg(Trpv1-icre)1Kldr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Slc17a6tm1.1Thna/Slc17a6tm1.1Thna
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Uchl1tm1Dgen/Uchl1tm1Dgen
Genetic Background: B6.129P2-Uchl1tm1Dgen/Mmnc

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0003243 abnormal dopaminergic neuron morphology "malformation or absence of the neurons that utilize dopamine as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Mapttm2Arbr/Mapt+,Shox2tm1.1(cre)Oki/Shox2+,Slc17a6tm1.1Thna/Slc17a6tm1.2Edw
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rai1tm2.1Luo/Rai1tm2.1Luo,Slc17a6tm2(cre)Lowl/?
Genetic Background: either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Thna/Slc17a6tm1.1Thna,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129/Sv * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Jder/Slc17a6tm1.1Jder,Emx1tm1(cre)Krj/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Krj Slc17a6tm1.1Jder

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc4rtm2Lowl/Mc4rtm2Lowl,Slc17a6tm2(cre)Lowl/Slc17a6+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Slc17a6tm1Kldr/Slc17a6tm1Kldr,Tg(PLAT-cre)116Sdu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0011001 absence of AMPA-mediated synaptic currents "absence of a measured amplitude, current density or response to stimulation of NMDA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fggtm1Lord/Fgg+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pax2tm1Mbu/Pax2tm1Mbu
Genetic Background: C3.129P2-Pax2tm1Mbu

Allelic Composition: Slc17a6tm1.1Kldr/Slc17a6tm1.1Kldr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Slc17a6tm1.2Jder/Slc17a6tm1.2Jder
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * C57BL/6J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Slc17a6tm1Lowl/Slc17a6tm1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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