ENSMUSG00000020894


Mus musculus

Features
Gene ID: ENSMUSG00000020894
  
Biological name :Vamp2
  
Synonyms : P63044 / Vamp2 / vesicle-associated membrane protein 2
  
Possible biological names infered from orthology : AC129492.3 / P63027
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69088490
Gene end: 69092384
  
Corresponding Affymetrix probe sets: 10377431 (MoGene1.0st)   1420833_at (Mouse Genome 430 2.0 Array)   1420834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112611
Ensembl peptide - ENSMUSP00000021273
NCBI entrez gene - 22318     See in Manteia.
MGI - MGI:1313277
RefSeq - NM_009497
RefSeq Peptide - NP_033523
swissprot - B0QZN5
swissprot - P63044
swissprot - Q8CHR4
Ensembl - ENSMUSG00000020894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC129492.3ENSG00000263620Homo sapiens
 VAMP2ENSG00000220205Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vamp1 / Q62442 / vesicle-associated membrane protein 1 / P23763*ENSMUSG0000003033781
Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*ENSMUSG0000002895564
Vamp4 / O70480 / vesicle-associated membrane protein 4 / O75379*ENSMUSG0000002669632
Vamp8 / vesicle-associated membrane protein 8 / Q9BV40*ENSMUSG0000005073232


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR016444  Synaptobrevin/Vesicle-associated membrane protein
 IPR028717  Vesicle-associated membrane protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006906 vesicle fusion IBA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IMP
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0017156 calcium ion regulated exocytosis IMP
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis TAS
 biological_processGO:0032869 cellular response to insulin stimulus IDA
 biological_processGO:0035493 SNARE complex assembly IEA
 biological_processGO:0043001 Golgi to plasma membrane protein transport IMP
 biological_processGO:0043308 eosinophil degranulation ISO
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060627 regulation of vesicle-mediated transport IMP
 biological_processGO:0061025 membrane fusion IMP
 biological_processGO:0090316 positive regulation of intracellular protein transport IMP
 biological_processGO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane IEA
 biological_processGO:1902259 regulation of delayed rectifier potassium channel activity IEA
 cellular_componentGO:0000322 storage vacuole IDA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISO
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0030672 synaptic vesicle membrane IDA
 cellular_componentGO:0031201 SNARE complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0042589 zymogen granule membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
 cellular_componentGO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IEA
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA
 molecular_functionGO:0000149 SNARE binding IEA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IDA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017022 myosin binding IEA
 molecular_functionGO:0017075 syntaxin-1 binding IEA
 molecular_functionGO:0019905 syntaxin binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a5mpc234H/Slc26a5mpc234H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a5mpc234H/Slc26a5mpc234H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lef1tm1Rug/Lef1tm1Rug
Genetic Background: involves: 129S2/SvPas

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

Allelic Composition: Vamp2tm1.1Jret/Vamp2tm1.1Jret
Genetic Background: B6.129-Vamp2tm1.1Jret

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lef1tm1Rug/Lef1tm1Rug
Genetic Background: involves: 129S2/SvPas

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lef1tm1Rug/Lef1tm1Rug
Genetic Background: involves: 129S2/SvPas

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Qkqk-2J/Qkqk-2J
Genetic Background: B6.Cg-Qkqk-2J/GrsrJ

 MP:0008504 abnormal adrenal chromaffin cell morphology "any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stx1btm1.1Sud/Stx1btm1.1Sud
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lef1tm1Rug/Lef1tm1Rug
Genetic Background: involves: 129S2/SvPas

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Plxnb2tm1c(EUCOMM)Wtsi/Plxnb2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000070570 Q3TXX4 / Slc17a7 / Vesicular glutamate transporter 1 / Q9P2U7* / solute carrier family 17 member 7*  / complex
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / reaction / complex
 ENSMUSG00000100241 Slc18a3 / solute carrier family 18 member A3 / Q16572*  / complex / reaction
 ENSMUSG00000027273 P60879 / Snap25 / Mus musculus synaptosomal-associated protein 25 (Snap25), transcript variant 4, mRNA. / P60880* / synaptosome associated protein 25*  / complex
 ENSMUSG00000027287 O09044 / Snap23 / synaptosomal-associated protein 23 / O00161* / synaptosome associated protein 23*  / reaction / complex
 ENSMUSG00000031840 Rab3a / P63011 / RAB3A, member RAS oncogene family / P20336*  / complex
 ENSMUSG00000007207 Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*  / complex
 ENSMUSG00000039361 Picalm / Q7M6Y3 / Phosphatidylinositol-binding clathrin assembly protein / Q13492*  / reaction / complex
 ENSMUSG00000035864 Syt1 / P46096 / synaptotagmin I / P21579* / synaptotagmin 1*  / complex






 

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