ENSMUSG00000027273


Mus musculus

Features
Gene ID: ENSMUSG00000027273
  
Biological name :Snap25
  
Synonyms : Mus musculus synaptosomal-associated protein 25 (Snap25), transcript variant 4, mRNA. / P60879 / Snap25
  
Possible biological names infered from orthology : P60880 / synaptosome associated protein 25
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F3
Gene start: 136713453
Gene end: 136782428
  
Corresponding Affymetrix probe sets: 10476512 (MoGene1.0st)   1416828_at (Mouse Genome 430 2.0 Array)   1447763_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105725
Ensembl peptide - ENSMUSP00000028727
NCBI entrez gene - 20614     See in Manteia.
MGI - MGI:98331
RefSeq - NM_011428
RefSeq - XM_017316761
RefSeq - NM_001291056
RefSeq - NM_001355254
RefSeq - NM_001355255
RefSeq - XM_017316758
RefSeq - XM_017316760
RefSeq Peptide - NP_035558
RefSeq Peptide - NP_001277985
RefSeq Peptide - NP_001342183
RefSeq Peptide - NP_001342184
swissprot - P60879
Ensembl - ENSMUSG00000027273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5TZ66ENSDARG00000020609Danio rerio
 Q5TZ66ENSDARG00000058117Danio rerio
 P60878ENSGALG00000009003Gallus gallus
 P60880ENSG00000132639Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O09044 / Snap23 / synaptosomal-associated protein 23 / O00161* / synaptosome associated protein 23*ENSMUSG0000002728758


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR000928  SNAP-25


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007269 neurotransmitter secretion IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0010975 regulation of neuron projection development IGI
 biological_processGO:0016082 synaptic vesicle priming IBA
 biological_processGO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
 biological_processGO:0031915 positive regulation of synaptic plasticity IMP
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0070201 regulation of establishment of protein localization IMP
 biological_processGO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
 biological_processGO:0099590 neurotransmitter receptor internalization IMP
 biological_processGO:1990926 short-term synaptic potentiation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031083 BLOC-1 complex ISS
 cellular_componentGO:0031201 SNARE complex ISS
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0036477 somatodendritic compartment IDA
 cellular_componentGO:0042734 presynaptic membrane IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044295 axonal growth cone ISO
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex ISO
 cellular_componentGO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
 cellular_componentGO:0098794 postsynapse IDA
 molecular_functionGO:0000149 SNARE binding ISO
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IDA
 molecular_functionGO:0048306 calcium-dependent protein binding ISS


Pathways (from Reactome)
Pathway description
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Other interleukin signaling
Neutrophil degranulation
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev,Krastm4Tyj/Krastm4Tyj
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001290 delayed eyelid opening "late average time for the first postnatal eye opening" [J:17792]
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Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+,Pax3Sp/Pax3+,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(MYC/ERT2)Gev/Gt(ROSA)26Sortm1(MYC/ERT2)Gev,Krastm4Tyj/Krastm4Tyj
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm66.1(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

Allelic Composition: Snap25tm2.1(cre)Hze/Snap25+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002280 abnormal intercostal muscle morphology "anomaly in the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0002897 blotchy skin "regions of spotted discoloration appearing in the dermal tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002914 abnormal endplate potential activity "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002920 reduced paired-pulse facilitation "decrease in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: B6.129-Tlr2tm1Kir Ldlrtm1Her

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Snap25Bdr/Snap25+
Genetic Background: involves: BALB/cAnNCrl

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0006087 increased body mass index "greater than normal average of a measure of weight for height" [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Snap25tm1Bark/Snap25tm1Bark
Genetic Background: B6.Cg-Snap25tm1Bark

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Snap25Bdr/Snap25+
Genetic Background: involves: BALB/cAnNCrl

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Snap25tm1Mtaka/Snap25tm1Mtaka
Genetic Background: B6N.129P2-Snap25tm1Mtaka

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Syt1tm4Sud/Syt1tm4Sud
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011613 decreased circulating ghrelin level "less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex
 ENSMUSG00000007207 Stx1a / O35526 / syntaxin 1A (brain) / Q16623* / syntaxin 1A*  / complex






 

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