ENSMUSG00000039361


Mus musculus

Features
Gene ID: ENSMUSG00000039361
  
Biological name :Picalm
  
Synonyms : Phosphatidylinositol-binding clathrin assembly protein / Picalm / Q7M6Y3
  
Possible biological names infered from orthology : Q13492
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D3
Gene start: 90130213
Gene end: 90213465
  
Corresponding Affymetrix probe sets: 10554839 (MoGene1.0st)   1443218_at (Mouse Genome 430 2.0 Array)   1446968_at (Mouse Genome 430 2.0 Array)   1451316_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146659
Ensembl peptide - ENSMUSP00000146541
Ensembl peptide - ENSMUSP00000147016
Ensembl peptide - ENSMUSP00000150861
Ensembl peptide - ENSMUSP00000051092
Ensembl peptide - ENSMUSP00000146386
Ensembl peptide - ENSMUSP00000146408
Ensembl peptide - ENSMUSP00000146501
Ensembl peptide - ENSMUSP00000146509
NCBI entrez gene - 233489     See in Manteia.
MGI - MGI:2385902
RefSeq - XM_006507605
RefSeq - XM_006507594
RefSeq - XM_006507595
RefSeq - XM_006507596
RefSeq - XM_006507597
RefSeq - XM_006507598
RefSeq - XM_006507599
RefSeq - XM_006507600
RefSeq - XM_006507601
RefSeq - XM_006507602
RefSeq - XM_006507603
RefSeq - XM_006507604
RefSeq - NM_001252520
RefSeq - NM_001252521
RefSeq - NM_001252522
RefSeq - NM_001252523
RefSeq - NM_001252524
RefSeq - NM_146194
RefSeq Peptide - NP_001239453
RefSeq Peptide - NP_666306
RefSeq Peptide - NP_001239449
RefSeq Peptide - NP_001239450
RefSeq Peptide - NP_001239451
RefSeq Peptide - NP_001239452
swissprot - Q3TD51
swissprot - A0A140LHQ8
swissprot - A0A1L1SUR7
swissprot - Q7M6Y3
swissprot - A0A140LHG9
Ensembl - ENSMUSG00000039361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 picalmaENSDARG00000012866Danio rerio
 picalmbENSDARG00000014137Danio rerio
 PICALMENSGALG00000039037Gallus gallus
 PICALMENSG00000073921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snap91 / synaptosomal-associated protein 91 / O60641* / synaptosome associated protein 91*ENSMUSG0000003341951


Protein motifs (from Interpro)
Interpro ID Name
 IPR008942  ENTH/VHS
 IPR011417  AP180 N-terminal homology (ANTH) domain
 IPR013809  ENTH domain
 IPR014712  Phosphoinositide-binding clathrin adaptor, domain 2
 IPR030412  Phosphatidylinositol-binding clathrin assembly protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007611 learning or memory IGI
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0016050 vesicle organization ISO
 biological_processGO:0016188 synaptic vesicle maturation IMP
 biological_processGO:0016197 endosomal transport ISO
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030100 regulation of endocytosis ISO
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0032880 regulation of protein localization ISO
 biological_processGO:0035459 cargo loading into vesicle IMP
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045056 transcytosis ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0048261 negative regulation of receptor-mediated endocytosis ISO
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0055072 iron ion homeostasis ISS
 biological_processGO:0072583 clathrin-dependent endocytosis IMP
 biological_processGO:0090647 modulation of age-related behavioral decline IGI
 biological_processGO:0097494 regulation of vesicle size ISO
 biological_processGO:0097753 membrane bending ISO
 biological_processGO:0098711 iron ion import across plasma membrane ISS
 biological_processGO:1900223 positive regulation of amyloid-beta clearance IMP
 biological_processGO:1901216 positive regulation of neuron death ISS
 biological_processGO:1902004 positive regulation of amyloid-beta formation IMP
 biological_processGO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
 biological_processGO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process IMP
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane ISO
 biological_processGO:2000009 negative regulation of protein localization to cell surface ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005905 clathrin-coated pit ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030122 AP-2 adaptor complex ISO
 cellular_componentGO:0030132 clathrin coat of coated pit ISO
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070381 endosome to plasma membrane transport vesicle ISO
 cellular_componentGO:0097418 neurofibrillary tangle ISS
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005545 1-phosphatidylinositol binding IEA
 molecular_functionGO:0017137 Rab GTPase binding ISO
 molecular_functionGO:0030276 clathrin binding IEA
 molecular_functionGO:0032050 clathrin heavy chain binding ISO
 molecular_functionGO:0035615 clathrin adaptor activity ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Picalmtm1.2Tmae/Picalmtm1.2Tmae
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Edaraddcr-2J/Edaraddcr-2J
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J

Allelic Composition: Picalmfit1-494SB/Picalmfit1-494SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmfit1-4397SB/Picalmfit1-4397SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmfit1-4226SB/Picalmfit1-4226SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmfit1-3452SB/Picalmfit1-3452SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Edaraddcr-2J/Edaraddcr-2J
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J

Allelic Composition: Picalmfit1-494SB/Picalmfit1-494SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmfit1-4397SB/Picalmfit1-4397SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmfit1-4226SB/Picalmfit1-4226SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Picalmfit1-3452SB/Picalmfit1-3452SB
Genetic Background: involves: BALB/cRl

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Qkqk-kt1/Qkqk-kt1
Genetic Background: involves: STOCK tw5

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002810 microcytic anemia "anemia in which the circulating erythrocyte corpuscular volume is smaller than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.2Tmae/Picalm+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalm+,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0005639 hemosiderosis "condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008388 hypochromic microcytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Thl/0,Picalmtm1.1Tmae/Picalmtm1.1Tmae
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Jak2tm1.2Ble/Jak2+,Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Picalmtm1.2Tmae/Picalmtm1.2Tmae
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Picalmtm1.2Tmae/Picalmtm1.2Tmae
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Picalmtm1.2Tmae/Picalmtm1.2Tmae
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011246 abnormal fetal liver hematopoietic progenitor cell morphology "any structural anomaly of a hematopoietic stem cell that resides in the fetal liver; in mice, this cell type is first observed at E10.5" [CL:0002353]
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Allelic Composition: Picalmtm1.2Tmae/Picalmtm1.2Tmae
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA * SJL

Allelic Composition: Picalmtm1.1Tmae/Picalmtm1.1Tmae,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Picalmtm1Towa/Picalmtm1Towa
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020894 Vamp2 / P63044 / vesicle-associated membrane protein 2 / P63027* / AC129492.3*  / complex / reaction
 ENSMUSG00000050732 Vamp8 / vesicle-associated membrane protein 8 / Q9BV40*  / reaction / complex
 ENSMUSG00000028955 Vamp3 / P63024 / vesicle-associated membrane protein 3 / Q15836*  / reaction / complex






 

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